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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 39 / No. 4 / Published : 2003-10

TOC : 4, and page :216 - 222

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Original Article :

The pattern of immunopathobiological response in oral mucosa to disclose the immunopathobiogenesis of candida albicans infection in patients with diabetes mellitus

Author :

  1. Harlina*1
  1. Department of Oral Pathology Hasanuddin University School of Dentistry Makassar

Abstract :

Candida albicans infection is often found in oral cavity of DM patients. However, the mechanism of immune response change resulted from the infection remains unclear. Information on factors and immune response change occurring in C. albicans infection remains rare, because in such condition the clinical manifestation has not been induced. C. albicans infection may develop to become candidiasis, a manifest infectious disease, and further it becomes pre-malignant candidal leukoplakia and malignant squamous cell carcinoma. C. albicans infection usually occurs locally, but it may disperse to visceral organs, leading to a fatality. C. albicans is a normal flora, while it is also an opportunistic pathogen because it may become a pathogen in immunocompromised condition. This may occur in DM patients since high blood glucose level will react non-enzymatically to protein, changing protein structure and function to become immunogen. This study was done to disclose the immunopathobiogenesis of oral C. albicans infection in patients with DM. Systemic and local immune response were compared between DM groups with high HbA1c level with and without C. albicans and non-DM with and without C. albicans. We found no difference between patients with high HbA1c level with C. albicans and those with high HbA1c level without C. albicans, and between patients with high HbA1c level with C. albicans and non-DM patients with C. albicans. Difference was found between patients with high HbA1c level without C. albicans and non-DM patients without C. albicans infection, and between non-DM patients with and without C. albicans infection. Local immune response also showed no difference in all groups. Three predominant discriminant variables were found in those groups, and these were described in an immunopathobiological pattern. Based on this pattern, it can be summarized that the role of Th1 produces IFN-γ, increases IgM switching to IgG, which is important to prevent the occurrence of C. albicans infection. Conclusively, immunopathobiological pattern can be used to disclose the immunopathobiogenesis of oral C. albicans infection in patients with DM.

Keyword :

immunopathobiogenesis, oral immune mucosa, C. albicans infection, Diabetes Mellitus,


References :

  1. Cotran RS, Kumar V, Collins T, (1999). Pathologic Basis of Disease, 6th Ed . Philadelphia : WB Saunders Company
  2. Hill RB, Lavi MF, (1980). Principles of Pathobiology. 3rd edition . Oxford : Oxford University Press


   


Archive Article

Cover Media Content

Volume : 39 / No. : 4 / Pub. : 2003-10
  1. Editorial vol 39 no 4 2003
  2. Opinion: medical molecular surgery
  3. Expression of bcl-2 and p53 in uterine cervical cancer
  4. The pattern of immunopathobiological response in oral mucosa to disclose the immunopathobiogenesis of candida albicans infection in patients with diabetes mellitus
  5. Efficacy of low dose sublingual immunotherapy in childhood asthma
  6. Stature and weight of indonesian children compared to nchs-reference
  7. Review article and clinical experience: the roles of micronutrients in the treatment of diabetes mellitus (focus on chromium and specific nutrients)
  8. The latest clinical epidemiological data of ischemic and hemorrhagic stroke patients in surabaya and the surroundings a hospital-based study
  9. Postnatal depression in three hospitals in surabaya
  10. The attitude improvement among community health center staff in managing the risk and resolving malnutrition in underfives by using estimation score
  11. The difference between adolescents with and without conduct disorder in assessing their family function
  12. Subtotal pancreatectomy for persistent hyperinsulinemia hypoglycemia in neonate (a case report)