UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 1 / Published : 2006-01

Order : 1, and page :1 - 5

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Original Article :

Toxoplasma gondii infection elicits the increase of fas expression on the trophoblast associated with the increase of trophoblast apoptosis

Author :

  1. Lucia Tri Suwanti*1
  2. Rochiman Sasmita*2
  3. Suhartono Taat Putra*3
  1. Department of Veterinary Parasitology, Airlangga University School of Veterinary Medicine
  2. Department of Veterinary Parasitology, Airlangga University School of Veterinary Medicine
  3. Department of Anatomic Pathology, Airlangga University School of Medicine

Abstract :

Toxoplasma gondii infection causes the increase of trophoblast apoptosis. The mechanism of trophoblast apoptosis in Toxoplasma gondii-infected pregnant mice has not been fully understood. We measured Fas expression on the tropboblast of infected-pregnant mice. The objective of this study was to proof the effect Toxoplasma gondii infection to the increase of Fas expression on pregnant mice trophoblast and the increase of Fas expression on pregnant mice trophoblast assosiate with increase of trophoblast apoptosis. Forty-eight pregnant Swiss mice were divided into 6 groups. Group I, first week gestation uninfected mice. Group II, first week gestation infected mice. Group III, second week gestation uninfected mice. Group IV, second week gestation infected mice. Group V, third week gestation uninfected mice. Group VI, third week gestation infected mice. Mice were infected with 1x103 tachizoites T. gondii doses by intraperitoneal. Four days post infection, mice were sacrificed, placenta was removed for observation Fas expression by immunohitochemistry staining and TUNEL ASSAY with Apop tag kit was used to observe trophoblast apoptosis index. The data were analysed by ANOVA and Regression. The result showed that Fas expression was significantly difference (p < 0.00) between infected mice and uninfected mice trophoblast. Fas expression was increasing on trophoblast of infected mice. Fas expression in first week gestation infected mice increased 7.4 times (from 3.65% to become 27.11%); in second week increased 7.2 times (from 5.37% to become 38.50%) and in the third week increased 3.6 times (from 11.64% to become 41.44%). The increase of Fas expression was significantly elevated when a high trophoblas apoptosis index in infected mice, rather than uninfected mice. We concluded that Toxoplasma gondii infection has effect on the increase of Fas expression on pregnant mice trophoblast and Fas expression associated with the increase of trophoblast apoptosis.

Keyword :

Toxoplasma gondii, Fas, trophoblast, apoptosis, pregnancy,


References :

S Aschkenazi,(2002) Differential regulation and function of the fas/fas ligand system in human trophoblast cells no info : Biol Reprod

S Straszewski,(2002) Differential regulation and function of the fas/fas ligand system in human trophoblast cells no info : Biol Reprod

KM Verwer,(2002) Differential regulation and function of the fas/fas ligand system in human trophoblast cells no info : Biol Reprod

H Foellmer,(2002) Differential regulation and function of the fas/fas ligand system in human trophoblast cells no info : Biol Reprod

T Rutherford,(2002) Differential regulation and function of the fas/fas ligand system in human trophoblast cells no info : Biol Reprod

G Mor,(2002) Differential regulation and function of the fas/fas ligand system in human trophoblast cells no info : Biol Reprod

DR Balkundi,(2000) Labor-associated changes in Fas ligand expression and function in human placenta no info : Pediatr Res

N Hanna,(2000) Labor-associated ch



Archive Article

Cover Media Content

Volume : 42 / No. : 1 / Pub. : 2006-01
  1. Toxoplasma Gondii Infection Elicits The Increase Of Fas Expression On The Trophoblast Associated With The Increase Of Trophoblast Apoptosis
  2. Effect Of Laser At Pishu Point On Amount And Function Of Pancreatic β Cells (rattus Norvegicus) Injected By Streptozotocin
  3. The Effects Of Unilateral Urethral Obstruction On Tubular Cells Apoptosis:an Experimental Study In Rabbits
  4. Antimicrobial Activities Of Andrographolide And Propolis Against Intracellular Mycobacterium Tuberculosis Phagocytosed By Monocytes Derived Macrophages
  5. The 2-methoxyethanol Toxicity Towards The Structures Of Plasma Membrane And Mitochondria Of The Rat’s Spermatozoa
  6. Genotyping Of Extended Spectrum Β-lactamase Escherichia Coli Strains From Clinical Specimens
  7. Multiresistance Pattern Of Extended Spectrum β-lactamase (esbl) – Escherichia Coli And Klebsiella Pnemoniae Strains
  8. Fev1-reversibility In House-dust Immunotherapy Compared With Inhaled Corticosteroid In The Treatment Of Childhood Asthma
  9. Trachoma In Pondok Pesantren Salafiyah Syafiiyah, Sukorejo, Situbondo, East Java. A Case Study
  10. Review Article : Depression In Post-myocardial Infarction Patients
  11. Review Article And Clinical Experience: The Mets: One Of The Major Threat To Human Health

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