UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 4 / Published : 2009-10

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Original Article :

Utilization of extract phaleria (phaleria macrocarpa) as a precaution against carbon tetrachloride induced hepatotoxicity in mice

Author :

  1. Reny I\'tishom *1
  2. Rochmah Kurnijasanti*2
  1. Department of Medical Biology Faculty of Medicine, Airlangga University
  2. Department of Medical Biology Faculty of Medicine, Airlangga University

Abstract :

The hepatoprotective activity of extract of mahkota dewa fruit’s (Phaleria macrocarpa) was investigated against Carbon Tetracloride (CCl4) induced hepatic damage. Carbon Tetracloride at a dose of 0,3 ml/kg body weight produced liver damage in mice as manifested by the rise in serum level of Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetat Transaminase (GOT) to 31.4286 ± 2.4398 and 87.1429 ± 2.4398 respectively, compared to respective control values of 23.0000 ± 1.7889 and 39.0000 ± 3.6968. Pretreatment of mice with mahkota dewa fruit’s extract at concentration of 2.5 ; 5; 10 mg/kg body weigth significantly prevent (p < 0.001) Carbon Tetracloride induced rise in serum enzymes and the estimated values of GPT was 27.2857 ± 1.9760 ; 22.8750 ± 2.1002 and 22.1667 ± 1.3239 respectively, and GOT was 53.0000 ± 8.6410 ; 45.1429 ± 3.4365 and 40.6667 ± 7.1740 respectively. The result indicate that the mahkota dewa fruit’s (Phaleria macrocarpa) extract possesses hepatoprotetective activity which probably related to its antioxidant activity.

Keyword :

Phaleria macrocarpa, hepatotoxic,


References :

  1. David. Z and T.D. Boyer, (1990). Hepatology A texbook of Liver Disease. Biopchemical Tests for Liver Disease. 2nd Ed. . - : W.B. Saunders Company
  2. Gitlin. N, (1990). Clinical Aspects of Liver Diseases Caused by Industrial and Environmental Toxins. In (Zakim D. ed) Hepatology Textbook of Liver Disease. 2 nd ed . Philadelpia : WB Saunders Company




Archive Article

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Volume : 45 / No. : 4 / Pub. : 2009-10
  1. Utilization of extract phaleria (phaleria macrocarpa) as a precaution against carbon tetrachloride induced hepatotoxicity in mice
  2. Effect of transventricular cerebrospinal fluid in patient with severe brain damage with thin acute subdural bleeding. a comparative study with decompression trepanation action
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