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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 38 / No. 3 / Published : 2002-07

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Original Article :

Vitamin a deficiency induce imbalance of iga, igg, and igm producing cells in mucosal immune response. an experimental animal study

Author :

      Abstract :

      Vitamin A deficiency may affect mucosal immune response. IgA, IgG, and IgM producing cells that produced SIgA, SIgG, SIgM. SIgA posses very important function in local humoral mucosal immune system. Decreasing population of these cells lead to the reduction of humoral mucosal immune response.The objective of the study was to elucidate the effect of vitamin A deficiency on the changes in distribution of IgA, IgG, and IgM producing cells in rat mucosal immune response. An experimental animal model with the use of male weaned Wistar rats were created. Vitamin A deficiency rats were made by using protocol (Sirishina, 1980). After randomization, the study population was divided into three groups, i.e., vitamin A deficient, control, and vitamin A deficient treated groups. Induction of immune response was done by administration of LPS. Serum level of vitamin A was measured by HPLC. Immunohistochemistry was used to express IgA, IgG, and IgM producing cells in the intestinal mucosa. Results: In the inductive site mucosal immune response (MIR) was significantly different from the IgA producing cells in the vitamin A deficient group and vitamin A deficient treated with p: 0.020, but not significantly different from IgG and IgM producing cells with p:1 and p: 0.713. In the effector site there was significant difference of the IgA producing cells in the vitamin A deficient group, vitamin A deficient treated with p: 0.009, but no significant difference of IgG and IGM producing cells with p:0.063 and p: 0.699. In the inductive site mucosal immune status (MIS), there was no significant difference between IgA, IgG, and IgM in vitamin A deficient and in vitamin A deficient treated group with p: 0.151, p:0.660, and p: 0.424. In the effector site there were significant difference of IgA, and IgG producing cells with p: 0.001 and p: 0.026. but there was no significant difference for IgM producing cells with p: 0.058. Conclusion: Vitamin A deficiency affect MIR in terms of decreasing expression of IgA producing cells, while the IgG and IgM producing cells are relatively stable. In the effector site, MIS, represented by IgA and IgG producing cells, are more affected. Administration of vitamin A, both MIR and MIS will return to normal.

      Keyword :

      Vitamin A deficiency, mucosal immune response, IgA, IgM, IgG producing cell,


      References :



           


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        9. A Glance At The Von Willebrand Factor In Dengue Virus Infection
        10. Vitamin A Deficiency Induce Imbalance Of Iga, Igg, And Igm Producing Cells In Mucosal Immune Response. An Experimental Animal Study
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