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Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 5 / No. 1 / Published : 2016-06

TOC : 3, and page :16 - 21

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Original Article :

The effect of ambon banana hump (musa paradisiaca var. sapientum) extract on histopathologic of rats (rattus norvegicus) jejunum inflammatory bowel disease

Author :

  1. Raditya Dimas Prayoga*1
  2. Rochmah Kurnijasanti*2
  3. Poedji Hastutiek*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This research aimed to study the effect of Ambon banana hump (Musa paradisiaca var. sapientum) extract to prevent destruction on jejunum, and as well as observe the difference of histopathology of indomethacine induced rat (Rattus norvegicus) in jejunum. This research used about 30 male rats 8 – 12 week, with average weight 150 gram. They were randomly selected and devided into 5 groups. K(-) was given 0,5 ml CMC Na 0,5% for 9 days and 0,5 ml corn oil was given on day 10. K(+) was given 0,5 ml CMC Na 0,5% for 9 days and then was induce by 30 mg/kg BW indomethacine once time on day 10. P1, P2, P3 were given ambon banana hump extract (P1: 20 mg/150 g BW, P2: 40 mg/150 g BW, P3: 80 mg/150 g BW) after that, were induced by 30 mg/kg BW Indomethacine once time on day 10. Each jejunum spesimen was processed and the histopathological changes were observed. Score of submucosal edema and epithelial integrity as qualitative data were analyzed with Kruskal Wallis test continued by Mann-Whitney test. The result were 1) ambon banana hump extract was not significant in reducing jejunum submucosal edema induced by indomethacine, 2) ambon banana hump extract was not significant in reducing jejunum epithelial integrity induced by indomethacine.

Keyword :

indomethacine, Musa paradisiaca var. sapientum,


References :

  1. Shargel, L., A, Yu, dan S, Wu. , (2005). Biofarmasetika dan Farmakokinetika Terapan.. Vol 2. Halaman 167-187 : Airlangga University Press. Surabaya


   


Archive Article

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Volume : 5 / No. : 1 / Pub. : 2016-06
  1. The effect of giving shallot extract (allium ascalonicum l) to histopathological feature of rat (rattus norvegicus) liver induced by alloxan
  2. The effect repeated exposures artemisinin of white pulp diameter and spleen index on mice (mus musculus) which infected by plasmodium berghei
  3. The effect of ambon banana hump (musa paradisiaca var. sapientum) extract on histopathologic of rats (rattus norvegicus) jejunum inflammatory bowel disease
  4. Effects of propolis on histology profile of kidney in male mice (mus musculus)
  5. Reactivity test of 30 kda protein aeromonas hydrophila, isolated by freshwater fish with indirect elisa
  6. Antibacterial activity of bitter leaf extract (andrographis panicullata, nees) against staphylococcus aureus isolates field with in vitro method
  7. Effect extract spirulina platensis on kidney histopathology of gouramy fish (osphronemus gouramylac.) infected with aeromonas hydrophila
  8. Isolation and identification of salmonella sp. on beef of cattle slaughtered at pegirian abattoir in surabaya
  9. Effect of laserpuncture exposure on bl-18 acupunture point’s to the level of sgot and sgpt in white rat (rattus norvegicus) were induced by paracetamol
  10. The effect of crude arthrospira sp in layer feed to optical density and immunoglobulin a levels
  11. The immersion effect of spirulina platensis extract on hepatopancreas of carp fish (osphronemus gouramy) that infected aeromonas hydrophila
  12. The effect of green bitter melon fruit flesh (momordica charantia l.) extract on mice (mus musculus) estrous cycle which superovulated with pmsg and hcg