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Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 3 / No. 1 / Published : 2014-06

TOC : 10, and page :56 - 62

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Original Article :

The effect of borax to duodenal histopathological changes in rats (rattus norvegicus)

Author :

  1. Muhammad Thohawi Elziyad P*1
  2. Ngakan Made Rai Widjaja*2
  3. Hani Plumeriastuti*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this study was to evaluate the histopathological changes in duodenum of wistar rats after giving borax using different subchronic toxicity doses. The research has been done on April, 2th 2012-May, 29th 2012 at Department of Pathology Veterinary, Faculty of Veterinary Medicine, University Airlangga. Twenty male rats (Rattus norvegicus strain Wistar) aged 45 days with BW 100 g were used. These animals were divided into four groups (P0, P1, P2, and P3). P0 were treated with sterile aquadest 0,5 ml/rats/day, P1 were treated with borax 19 mg/rats/day, P2 were treated with borax 26 mg/rats/day, and P3 were treated with borax 37 mg/rats/day. This research has been conducted for 14 days to determine the toxic effects of borax on the duodenum. The data were compared using Kruskal-Wallis test and Mann-Whitney test. Statistical comparisons were performed using SPSS v20.0 for windows. The result showed that borax significantly caused cloudy swelling, congestion, necrosis and erosion of the villi on duodenal histopathology (p<0,05).    

Keyword :

borax, disodium tetraborate decahydrate, duodenal histopathology,

References :

  1. Dieter, M.P. , (1994). Toxicity and carcino-genicity studies of boric acid in male and female B6C3F1 mice. . Amerika : Environ. Health Persp. 102(Suppl 7):93-97.
  2. Rippey, J. J. . , (1994). General Pathologi. . Perth Western. Australia. : Witwatersrand University Press. 22-40
  3. Wagner, H., And P. Wolff. , (1977). New Natural Products And Plants Drugs With Pharmacologycal Biologycal or Therapeutical Activity. . New York. : Springer-Verlag. Berlin. Heiderberg. 37-38


Archive Article

Cover Media Content

Volume : 3 / No. : 1 / Pub. : 2014-06
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  5. Identification and isolation of influenza virus (h5) in pig in north sumatra
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  8. Effect of phyllanthus niruri linn extracts on blood glucose levels in diabetic rats (rattus norvegicus) induced by alloxan
  9. The effect of meniran extract (phyllanthus niruri linn.) against sgot and sgpt level of white rats (rattus norvegicus) induced by alcohol
  10. The effect of borax to duodenal histopathological changes in rats (rattus norvegicus)