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Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 5 / No. 1 / Published : 2016-06

TOC : 1, and page :1 - 7

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Original Article :

The effect of giving shallot extract (allium ascalonicum l) to histopathological feature of rat (rattus norvegicus) liver induced by alloxan

Author :

  1. Ni Komang Aprilina Widi Suputri*1
  2. Ajik Azmijah *2
  3. Retno Bijanti*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak bawang merah (Allium ascalonicum L) terhadap gambaran histopatologi hepar tikus putih (Rattus norvegicus) yang diinduksi aloksan. Aloksan diinjeksikan intaperitoneal dengan dosis 120 mg/kg BB (dosis tunggal). Sejumlah total 20 ekor tikus putih jantan galur wistar berumur tiga bulan digunakan pada penelitian ini. Tikus putih dikelompokkan menjadi lima kelompok. 1) kelompok kontrol negatif (K-)diterapi dengan CMC Na 0,5%, 2) kelompok kontrol positif (K+) diterapi dengan metformin 45 mg/kg BB sebagai obat standar, 3) ekstrak bawang merah (Allium ascalonicum) 250 mg/kg BB (P1), 4) ekstrak bawang merah (Allium ascalonicum) 500mg/kg BB (P2), 5) ekstrak bawang merah (Allium ascalonicum) 750 mg/kg BB (P3). Tikus putih diterapi selama 14 hari. Data dari penelitian ini dianalisis menggunakan Uji Kruskal Wallis, lalu dilanjutkan dengan Uji Mann-Whitney. Hasil dari penelitian ini adalah bawang merah (Allium ascalonicum) dapat memperbaiki gambaran histopatologi hepar tikus putih yang diinduksi aloksan.

Keyword :

Allium ascalonicum, alloxan, liver, Rattus norvegicus,


References :

  1. Arimbi, Ajik, A., Roesno, D., Hani, P., Thomas, V., Djoko, L, (2013). Buku Ajar Patologi Umum Veteriner. 1 : Airlangga University Press
  2. Azuma, K., Minami, Y., Ippoushi, K., dan Terao, J, (2007). Lowering Effects of Onion Intake on Oxidative Stress Biomarkers in Streptozotocin-Induced Diabetic Rats. 40 : 131-140. : J.Clin Biochem Nutr


   


Archive Article

Cover Media Content

Volume : 5 / No. : 1 / Pub. : 2016-06
  1. The effect of giving shallot extract (allium ascalonicum l) to histopathological feature of rat (rattus norvegicus) liver induced by alloxan
  2. The effect repeated exposures artemisinin of white pulp diameter and spleen index on mice (mus musculus) which infected by plasmodium berghei
  3. The effect of ambon banana hump (musa paradisiaca var. sapientum) extract on histopathologic of rats (rattus norvegicus) jejunum inflammatory bowel disease
  4. Effects of propolis on histology profile of kidney in male mice (mus musculus)
  5. Reactivity test of 30 kda protein aeromonas hydrophila, isolated by freshwater fish with indirect elisa
  6. Antibacterial activity of bitter leaf extract (andrographis panicullata, nees) against staphylococcus aureus isolates field with in vitro method
  7. Effect extract spirulina platensis on kidney histopathology of gouramy fish (osphronemus gouramylac.) infected with aeromonas hydrophila
  8. Isolation and identification of salmonella sp. on beef of cattle slaughtered at pegirian abattoir in surabaya
  9. Effect of laserpuncture exposure on bl-18 acupunture point’s to the level of sgot and sgpt in white rat (rattus norvegicus) were induced by paracetamol
  10. The effect of crude arthrospira sp in layer feed to optical density and immunoglobulin a levels
  11. The immersion effect of spirulina platensis extract on hepatopancreas of carp fish (osphronemus gouramy) that infected aeromonas hydrophila
  12. The effect of green bitter melon fruit flesh (momordica charantia l.) extract on mice (mus musculus) estrous cycle which superovulated with pmsg and hcg