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Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 3 / No. 1 / Published : 2014-06

TOC : 9, and page :50 - 55

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Original Article :

The effect of meniran extract (phyllanthus niruri linn.) against sgot and sgpt level of white rats (rattus norvegicus) induced by alcohol

Author :

  1. Abdul Khamid*1
  2. Rahaju Ernawati*2
  3. Iwan Sahrial Hamid*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this study was to determine the effect of meniran extract (Phyllanthus niruri Linn.) to decrease the levels of SGOT and SGPT in Wistar rats induced alcohol. The research has ben done on February, 24th 2014-April, 8th 2014 at Faculty of Medicine, University of Airlangga was continued at BBLK Surabaya, East Java. Twenty five male rats (Rattus norvegicus strain Wistar) aged 2-3 months with an average weight of 150-200 g. These animals were divided into five groups (P0, P1, P2, P3, and P4). P0 were treated with CMC Na 1% 1 ml/rats/day, P1 were treated with alcohol 25% 1 ml/rats/day, P2 were treated with extract of meniran 0,63 mg/rats/day and alcohol 25% 1 ml/rats/day and , P3 were treated with extract of meniran 2,7 mg/rats/day and alcohol 25% 1 ml/rats/day, and P4 were treated with extract of meniran 6,26 mg/rats/day.This research has been conducted for 21 days to determine the decrease in SGOT and SGPT levels. The data were compared using ANOVA test and Tukey's test. From the statistical test showed that the extract meniran not show significant differences (p> 0.05) towards decreased levels of SGOT and SGPT. In this study the variation in each treatment group were high and exposure to alcohol is too short. The results showed that the meniran extract  did not show significant differences in the decrease in the levels of SGOT and SGPT in rats induced by alcohol.     

Keyword :

Phyllanthus niruri Linn, alcohol, SGOT, SGPT,

References :

  1. Jawi IM, Sutirta-Yasa WP, Saputra H. , (2007). Gambaran histologis hepar serta kadar SGOT dan SGPT darah mencit yang diberikan alkohol secara akut dan kronis. . Jakarta : Dexa Media, 1(20) : 23-26.
  2. Kardinan, A. dan F.R. Kusuma. , (2004). Meniran Penambah Daya Tahan Tubuh Alami.. Tangerang. : Agromedia Pustaka.
  3. Suharmi S dan Ustariana W. , (2000). Pengaruh senyawa antihepato-toksik dalam infusa herba (Phy-llantus niruri L.) terhadap efek toksik aflatoksin B1 (20 μg/ml) pada hepatosit tikus (Rattus norvegicus) terisolasi. . Surabaya : Berkala Ilmu Kedokteran. 32:91-95.


Archive Article

Cover Media Content

Volume : 3 / No. : 1 / Pub. : 2014-06
  1. Detection of avian influenza antibody h5 subtype on bearded pig (sus barbatus) in central kalimantan
  2. The effect of infusion of tekelan (chromolaena odorata l.) leaf to wound healing incision on mice (mus musculus) were infected by staphylococcus aureus
  3. Activity test of krisan flower (chrysanthemum morifolium ramat) exstract on stable fly (stomoxys calcitrans geof.) mortality by in vitro
  4. Epidemiology of avian influenza virus (h5) from duck outbreak in the 2012-2013 in east java
  5. Identification and isolation of influenza virus (h5) in pig in north sumatra
  6. Effect of margarine and shortening trans fatty acid on rats (rattus norvegicus) hdl cholesterol level
  7. Toxicity test of ethanol extract of red roses (rosa damascena mill) by brine shrimp lethality test (bslt) method
  8. Effect of phyllanthus niruri linn extracts on blood glucose levels in diabetic rats (rattus norvegicus) induced by alloxan
  9. The effect of meniran extract (phyllanthus niruri linn.) against sgot and sgpt level of white rats (rattus norvegicus) induced by alcohol
  10. The effect of borax to duodenal histopathological changes in rats (rattus norvegicus)