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Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 7 / No. 1 / Published : 2018-06

TOC : 1, and page :1 - 7

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Original Article :

The effect of onion (allium ceppa l.) ethanol extract to blood glucose level of rats (rattus norvegicus) induced by alloxan

Author :

  1. Sri Agus Sudjarwo*1
  2. Eza Cahya Prawita *2
  3. Sri Mumpuni Sosiawati*3
  1. Dosen Fakultas Kedokteran Hewan
  2. Mahasiswa Fakultas Kedokteran Hewan
  3. Mahasiswa Fakultas Kedokteran Hewan

Abstract :

This study was obtained to determine antidiabetic effect of repeated oral administration of onion extract (Allium ceppa L) in alloxan induced diabetic rats (Rattus norvegicus). Alloxan were intraperitoneally injected 120 mg/KgBW (single dose). A total of twenty male wistar rats of three months old were used this study. The rats were divided into five groups. 1) negative control group (K-) was treated by CMC Na 0.5 %, 2) positive control group (K+) had been inducted by alloxan and treated by CMC Na 0.5 %, 3) group 1 (P1) had been inducted by alloxan and treated by extract of Allium ceppa L 200 mg/KgBW, 3) group 2 (P2) had been inducted by alloxan and treated by extract of Allium ceppa L 400 mg/KgBW 4) group 3 (P3) had been inducted by alloxan and treated by extract of Allium ceppa L 800 mg/KgBW. Blood specimen were collected from coccygealis vein, then analyzed using easytouch glucometer. The result of this study showed that Allium ceppa L extraxt had high antidiabetic potential which decreased the blood glucose in 14 days post treatment. Allium ceppa L consisted of allyl prophyl disulphide and queercetin that could reduced the blood glucose level. After 14 days post treatment, the averaged result of blood glucose levels in dose 200 mg/KgBW. (P1) and dose 800 mg/KgBW (P3) didn’t approached the negative control (K-)’s therefore the effective dose of Allium ceppa L that could reduced the blood glucose level was 400 mg/KgBB.

Keyword :

Allium ceppa L, Alloxan, Antidabetic, Blood glucose, Rats,


References :

  1. Astawan, M. dan A.L. Kasih, (2009). Khasiat Warna-Warni Makanan. August 2nd : Gramedia Pustaka Utama, Jakarta
  2. Oyenihi, A. B., N. L. Brookers., O. O. Oguntibeju, and G. Aboua, (2014). Antioxidant-Rich Natural Products and Diabetes Melitus. Antioxidant-Antidiabetic Agents and Human Health, Prof. Oluwafemi Oguntibeju Ed. - : Department of Biochemistry. School of Life Science. University of Kwazulu-Natal. South Africa
  3. Pineda, M. H. and M. P. Dooley, (2003). Veterinary Endocrinology and Reproduction. 5th ed. 142, 158. : Iowa State Press. Iowa


   


Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2018-06
  1. The effect of onion (allium ceppa l.) ethanol extract to blood glucose level of rats (rattus norvegicus) induced by alloxan
  2. Antifungal activity of pomegranate peel tablet on candida albicans: an in-vitro study
  3. The effects of green tea leaves extract as nephroprotector in mice (mus musculus) that induced by mercury chloride
  4. The potential of onion (allium cepa l.) ethanol extract on the numbers of endocrine cells in the islets of white rats langerhans pancreatic tissue (rattus norvegicus) induced by alloxan
  5. The effectivity test of ethanol extract of yacon leaves (smallanthus sonchifolius) on the necrotic hepatocyte of white rat induced by alloxan
  6. The effectivity of onion (allium cepa l.) ethanol extract on kidney histopathological appearence of hyperglicemic white rat (rattus novergicus)
  7. Index of erythrocytes kintamani bali dog in east java based on mcv, mch, and mchc
  8. Description of hematological value in water monitor (varanus salvator bivittatus) in east java
  9. Effectiveness of binahong leaves gel ekstrak (anredera cordifolia (tenore) steenis) to burn wound of mice (mus musculus) on inflammation observation
  10. Effect of meniran extract (phyllanthus niruri linn) on decrase total leukocyte and number of neutrophils blood of infected broiler chick by mycoplasma gallisepticum
  11. The effect of bay leaf (eugenia polyantha) extract immersion on the total bacterial count in green mussels (perna viridis)
  12. The effect of spirulina platensis on testosterone concentration of male rattus norvegicus under stress condition