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Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 4 / No. 2 / Published : 2015-12

TOC : 5, and page :106 - 112

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Original Article :

The influence of sambiloto leaf (andrographis paniculata) extract as an imunostimulator against the proliferation of lymphocyte

Author :

  1. Nuril Fadhilah*1
  2. Dewa Ketut Meles*2
  3. Adi Prijo Rahardjo*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Sambiloto leaf (Andrographis paniculata) extract is a herbal medicine that used to be an imunostimulator when the body is getting ill and decline in body function. The purpose of this research is to prove that therapy of sambiloto leaf (Andrographis paniculata) extract as imunostimulator can increase the proliferation of lymphocyte blood cells in mice with Salmonella typhimurium infection. Twenty five mice were divided into five experimental groups on the therapy of sambiloto leaf (Andrographis paniculata) extract for 6 days, and twenty five mice others on the therapy of sambiloto leaf (Andrographis paniculata) extract for 13 days. All groups, except K(-), infected with ½ ml of 105 cells/ml Salmonella typhimurium intraperitoneally. After five days incubation period, mice were given extract of sambiloto leaf(Andrographis paniculata) in different doses, which were P1 with 4.42 mg/25g BW/day, P2 with 6.82 mg/25g BW/day, P3 with 9.25 mg/25g BW/day, while P0 is an experimental group which not given on therapy of sambiloto leaf (Andrographis paniculata) extract. The data of this study was analyzed with ANOVA according to the completely randomized factorial sampling design, if F value is higher than Ftable continued by Tukey HSD test (Honestly Significant Difference). The result of this research showed that there were no significant differences (p>0.05) between treatment groups in increasing number of absolute lymphocyte cells in the blood of mice with Salmonella typhimurium infection.

Keyword :

sambiloto (Andrographis paniculata), Salmonella typhimurium, infectious disease, lymphocyte, mice,

References :

  1. Kusmardi, S. Kumala dan E. E. Triana. . , (2007). Efek Imunomodulator Ekstrak Daun Ketepeng Cina (Cassia alata L.) Terhadap Akti¬vitas dan Kapasitas Fagositosis Makrofag. . 11 (2), 50-53. : Makara Kesehatan.
  2. Pribadi, E. R. , (2009). Pasokan dan Permintaan Tanaman Obat Indonesia Serta Arah Penelitian dan Pengembangannya. . 8 (1), 52-64 : Per¬spek¬tif.
  3. Dewoto, H. R. . , (2007). Pengembangan Obat Tradisional Indonesia Menjadi Fitofarmaka. . 57 (7). : Majalah Kedokteran Indonesia. Jakarta.


Archive Article

Cover Media Content

Volume : 4 / No. : 2 / Pub. : 2015-12
  1. The effect of giving vitamin c on endosulfan induced in histopathologic liver of mice (mus musculus)
  2. Influence of hibiscus sabdariffa l. calyx on alveolar histopathological feature of cigarette smoke exposed mice
  3. The effect of l-arginine orally on the the histologycal of seminiferous tubules of rabbit (oryctolagus cuniculus) testicular
  4. Infusum cincau green leaves as the use inflammatory gastric on white rat (rattus norvegicus ) induced use caffeine with inspection histopathology
  5. The influence of sambiloto leaf (andrographis paniculata) extract as an imunostimulator against the proliferation of lymphocyte
  6. Effects of plant wood yellow leaf extract (arcangelisia flava merr) as to prevent hepatic dysfunction examination levels of bilirubin, sgot sgpt and serum blood on white rat (rattus norvegicus)
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  12. Rosella (hibiscus sabdariffa linn) extract as hepatoprotector on lead poisoning