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Jurnal Farmasi dan Ilmu Kefarmasian

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Vol. 1 / No. 1 / Published : 2014-01

TOC : 4, and page :16 - 19

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Original Article :

Aktivitas antiviral batang eucalyptus globulus terhadap virus hepatitis c jfh1a

Author :

  1. Titania Puspa Versiati*1
  2. Achmad Fuad Hafid *2
  3. Aty Widyawaruyanti*3
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

In vitro antiviral activity of Eucalyptus globulus stem against Hepatitis C Virus has been done. Previous studies showed that 80% ethanol  extract of Eucalyptus globulus stems has potential activity as an antihepatitis C virus against J6/JFH1 with IC50 value of 43.0 µg /ml. The aim of this study was to determine the anti-hepatitis C activity of extract and fractions of Eucalyptus globulus stems against 2a strain of  JFH1a hepatitis virus. The 80% ethanol extract and dichloromethane, ethyl acetate, butanol and water fraction were tested for their antiHCV activity. The results showed that the ethanol extract of Eucalytus globulus stems,  dichloromethane, ethyl acetate, and butanol fraction have activity in inhibiting the viral infection of cells with IC50 value of 10.19 µg/ml; 1.64 µg/mL; 10.49 µg/mL; and 18.78 µg/mL respectively. The water fraction was not  active with IC50 value of 205.79 µg/ml. Phytochemical screening using thin layer chromatography shown that the active fractions contained compounds known as terpenoids and flavonoids. Further studies of compounds that have anti-hepatitis C activity are needed.

Keyword :

Eucalyptus globulus, anti-HCV, JFH1a, IC50, ethanol extract,


References :

  1. Lila BM, Sakina S, Khodir M, (2012). Antioxidant Effects and Phytochemical Analysis of Crude and Chromatographic Fractions Obtained from Eucalyptus globulus bark. Afrika : African Journal of Biotechnology
  2. Wahyuni TS, Tumewu L, Permanasari AA, Apryani E, Adianti M, Rahman A, et al, (2013). Antiviral Activities of Indonesian Medicinal Plants in The East Java Region Against Hepatitis C Virus. - : Virology Journal
  3. Ashfaq UA, Masoud MS, Nawaz Z, Riazuddin S, (2011). Glycyrrhizin as Antiviral Agent Against Hepatitis C Virus. - : Journal of Translational Medicine
  4. El-Adawi H, El-Demellawy M, El-Wahab AA, (2011). Some Medicinal Plant Extract Exhibit Potency Against Viral Hepatitis C. - : Journal of Bioscience and Technology
  5. Javed T, Ashfaq UA, Riaz S, Rehman S, Riazuddin S, (2011). In-vitro Antiviral Activity of Solanum nigrum Against Hepatitis C Virus. - : Virology Journal


   


Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2014-06
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  3. Pelepasan gentamisin dari pelet bovine-hydroxyapatite-gelatin sebagai sistem penghantaran obat dan pengisi tulang
  4. Aktivitas antiviral batang eucalyptus globulus terhadap virus hepatitis c jfh1a
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