UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 2 / No. 1 / Published : 2015-10

Order : 7, and page :31 - 33

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Original Article :

Aktivitas penghambat asetilkolinesterase ekstrak etanol 96 persen daun syzygium cumini, syzygium aromaticum, syzygium polyanthum dan syzygium aquaeum

Author :

  1. Dody Anggah Saputra*1
  2. Abdul Rahman*2
  3. Idha Kusumawati*3
  1. 1Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi Universitas Airlangga
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer’s disease, senile dementia, ataxia and myasthenia gravis. A  thin-layer chromatography (TLC) autography was used to screen for finding better AChE inhibitors from natural resources. Using this methods this research showed that each of ethanol extracts of Syzygium cumini leaves, Syzygium aromaticum leaves, Syzygium polyanthum leaves, Syzygium aquaeum leaves had an acetylcholinesterase inhibitors activity.

Keyword :

Syzygium cumini, Syzygium aromaticum, Syzygium polyanthum, Syzygium aquaeum, Acetylcholinesterase inhibitors,


References :

Camps P, El-Achab R, Morral J, Torrero DM, Badia A, Banos JE, Vivas NM, Barril X, Orozco M, Luque FJ,(2000) New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer’s disease 43: 4657-4666 : J Med Chem

Jung M, and Park M,(2007) Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa 12, 2130-2139 : Molecules

Lopes EMC, Carreira RC, Agripino DG, Torres LMB, Cordeiro I, Bolzani VS, Machado SCD, Young MCM,(2008) Screening for antifungal, DNA-damaging and anticholinesterasic activities of Brazilian plants from the Atlantic Rainforest - Ilha do Cardoso State Park 655 – 660 : Revista Brasileira de Farmacognosia Brazilian Journal of Pharmacognosy 18 (Supl.)

Niño J, Hernández JA, Correa YM, Mosquera OM,(2006) In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora Vol. 101, (7): 783-785 : Mem Inst Oswaldo Cruz

Katzung BG,(2007



Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2015-06
  1. Formulasi Losio Antinyamuk Dengan Zat Aktif Minyak Atsiri Lantana Camara Linn
  2. Development Potentiometric Sensor-coated Wire Cyanide Ion Selective Electrode Based Aliquat336 Membranes For Determination Cyanide In Gadung (dioscorea Hispida Dennus)
  3. Studi In Silico Gendarusin A, B, C, D Dan E Untuk Prediksi Aktivitas Terhadap Enzim Cyp17a1 Sebagai Afrodisiaka
  4. Isolasi Senyawa Terpenoid Dari Fraksi N-heksana Daun Marsilea Crenata Presl. Pada Hasil Kcv Fraksi No.2
  5. Pengaruh Pasta Tomat (solanum Lycopersicum L.). Pada Pertumbuhan Dan Daya Hambat Lactobacillus Acidophilus Fncc-0051 Dan Lactobacillus Plantarum Fncc-0027 Terhadap Candida Albicans
  6. Aktivitas Antibakteri Susu Probiotik Lactobacilli Terhadap Bakteri Penyebab Diare (escherichia Coli, Salmonella Typhimurium, Vibrio Cholerae)
  7. Aktivitas Penghambat Asetilkolinesterase Ekstrak Etanol 96 Persen Daun Syzygium Cumini, Syzygium Aromaticum, Syzygium Polyanthum Dan Syzygium Aquaeum

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