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Jurnal Farmasi dan Ilmu Kefarmasian

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Vol. 1 / No. 2 / Published : 2014-12

TOC : 4, and page :48 - 54

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Original Article :

Pengaruh sistem miroemulsi tipe w/o terhadap karakteristik sediaan dan pelepasan natrium diklofenak (perbandingan konsentrasi surfaktan (span 80-tween 80): kosurfaktan (etanol 96%) = 6:1 dalam basis gel hpmc 4000)

Author :

  1. Nailul Ghayah*1
  2. Tristiana Erawati*2
  3. Esti Hendradi*3
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

The aim of this study was to observe the effect of microemulsion system w/o type on the characteristics of dosage form and release of diclofenac sodium in HPMC 4000 gel base. The ratio of surfactant (Span 80-Tween 80): cosurfactant (ethanol 96%), was used to make microemulsion is 6:1. Diclofenac sodium with emulsion in gel base was used as comparator. The evaluation included organoleptic, pH, spread diameter measurement of zero load, and also diclofenac sodium release test from gel base of each formula. Data from pH test, spread diameter measurement of zero load, and flux of drug release test were evaluated based on independent sample t-test. Data analysis showed that pH for microemulsion system in gel base (formula I) was 6.59±0.006 and emulsion system in gel base (formula II) was 6.55±0.047. Spread diameter measurement of zero load for formula I was 7.5±0.10 cm and for formula II was 12.7±0.21 cm. Those data was analyzed using independent sample t-test with degree of confident 95% (α=0.05). The result showed that there was a significant difference between two formulas in spread diameter of zero load but no significant difference in pH. Then, drug release test was carried out with Erweka Dissolution Tester Type DT 820 with apparatus 5 paddle overdisk in phosphate buffer 7.4±0.05, temperature 32°C and paddle rotation speed 100 rpm. The rate of diclofenac sodium release in microemulsion system in gel base was 48.4±0.52 µg/cm2/√minute. 

Keyword :

diclofenac sodium, microemulsion, drug release, HPMC,


References :

  1. Tjay TH, Rahardja K, (2007). Analgetika anti radang dan obat-obat rematik. Jakarta : PT Elex Media Komputindo
  2. Ramadani A, (2011). Karakterisasi Sediaan dan Uji Pelepasan Natrium Diklofenak dengan Sistem Mikroemulsi W/O dari Basis Gel Carbomer 940. Surabaya : Fakultas Farmasi Universitas Airlangga
  3. Budavari , (1996). The Merck Index 13th Edition. New Jersey : Merck & Co. Inc
  4. Katzung BG, (2006). Basic and Clinical Pharmacology 9th Ed. London : Prentice- Hall International Inc
  5. Sweetman SC, (2009). Martindale, The Complete Drug Reference. Ed 36th, Volume I. London : Pharmaceutical Press


   


Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2014-12
  1. Evaluasi mutu pelayanan di apotek komunitas kota kendari berdasarkan standar pelayanan kefarmasian
  2. Permasalahan terkait obat antihipertensi pada pasien usia lanjut di poli geriatri rsud dr.soetomo, surabaya
  3. Studi in silico gendarusin a, b, c, d, dan e untuk prediksi absorbsi dan aktivitas terhadap hialuronidase (ec 3.2.1.35)
  4. Pengaruh sistem miroemulsi tipe w/o terhadap karakteristik sediaan dan pelepasan natrium diklofenak (perbandingan konsentrasi surfaktan (span 80-tween 80): kosurfaktan (etanol 96%) = 6:1 dalam basis gel hpmc 4000)
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  6. Perbandingan aktivitas antioksidan ekstrak aseton tomat segar dan pasta tomat terhadap 1,1-diphenyl-2-picrylhidrazyl (dpph)
  7. Uji aktivitas ekstrak biji sirsak (annona muricata l.) terhadap sel kanker mamalia secara in vitro