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VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 6 / No. 1 / Published : 2017-08

TOC : 6, and page :25 - 29

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Original Article :

The effect of kikolod (isotoma longiflora (l) presl.) leave's extractto histopatology of incision wound healing in mice (mus musculus)

Author :

  1. Putri Indra Irawan*1
  2. Chairil Anwar*2
  3. Sri Agus Soedjarwo*3
  4. I Komang Wiarsa Sardjana*4
  5. Lilik Maslachah*5
  6. Arimbi*6
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan
  5. Dosen Fakultas Kedokteran Hewan
  6. Dosen Fakultas Kedokteran Hewan

Abstract :

This research’s aim is to find out the effect of Kitolod leaves’ extract in incision wound healing. This research consists of making incision wound on the mice’s back and cured by many treatments, Povidone Iodine 10% ointment (K+), Vaseline album (K-), extract ointments which consist of 5% (P1), 10% (P2), and 20% (P3) concentration for 6 days. The wound tissues were obatain to observe the fibroblast and fibrocyte, and the collagen density. Histopathological examination was done and data analyzed for the sum of fibroblast and fibrocyte used ANOVA followed with Duncan Test, while scoring of collagen density used Kruskal-Wallis Test followed with Mann Whitney Test. The result showed there was significant difference (p<0,05) between K+ to all treatments except P2 both the sum of fibroblast and fibrocyte cells, and the collagen density, but insignificantly different (p>0,05) between K+ and P2. The increase of the fibroblast and fibrocyte, and the collagen density in wound healing can strengthen the wound. The conclusion of these research was 10% of Kitolod leaves’ extract ointment can accelerate wound healing process by increasing the number of fibroblast and fibrocyte cells, and the collagen density.

Keyword :

kikolod leaves extract, fibroblast, fibrocyte, collagens, mice,


References :

  1. Basirun, (2010). Efek antiinflamasi ekstrak daun dan bunga Kitolod (Isotoma longiflora Presl.) terhadap inflamasi buatan pada tikus putih janjan galur wistar.. - : Tesis. Fakultas Kedokteran Universitas Gajah Mada: Yogyakarta.
  2. Cushnie, T.P.T., Cushnie, B., and Lamb, A.I., (2014). Alkaloids : An Overview of Their Antibacterial, Antibiotic-Enhancing and Antivirulence Activities. . 44 (2014) 377-386. : International Journal of Antimicrobial Agents
  3. Hirawan, H., Rahardjo, dan Raharjoe P.S. , (2010). Pengaruh Sanguin Deproteinasi terhadap Kecepatan Pembentukan Kolagen Pasca Odontektomi. . Vol. 1, No. 3, Oktober 2010 : 99-103 : Jurnal Kedokteran Gigi


   


Archive Article

Cover Media Content

Volume : 6 / No. : 1 / Pub. : 2017-08
  1. The case of digestive disorders in older cat (felis catus) based on medical history records at veterinary teaching hospital faculty of veterinary medicine universitas airlangga surabaya period 2014 -2016
  2. The potential for environmental pollution from the feces of worm infected dogs in surabaya
  3. The effectivity of gel extract binahong leaf (anredera cordifolia (ten.) steenis) on the incision wound in mice (mus musculus) by observation of wound area leangth and wound healing
  4. The effect of laserpuncture on heart rate, respiratory rate, body temperature and energy cost of locomotion of indonesian thoroughbred horse
  5. Comparison of hematologic value between kintamani dogs (canis lupus familiaris) and local dogs (canis familiaris)
  6. The effect of kikolod (isotoma longiflora (l) presl.) leave's extractto histopatology of incision wound healing in mice (mus musculus)
  7. The effect of okra (abelmoschus esculentus) extract ointment on topically on the rate wound healing process of skin burn on rat (rattus norvegicus) as model animals
  8. The influence of gel extract binahong leaf (anredera cordifolia (ten.) steenis) to observe macrophague cells and burn wound diameter degree ii in mice (mus musculus)
  9. Effectiveness of binahong leaves gel extract (anredera cordifolia (ten.) steenis) to reduce the number of pmn cells in incision wound healing processes of male mice (mus musculus)