UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Ners

ISSN 1858-3598

Vol. 7 / No. 1 / Published : 2012-04

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Original Article :

Ekspresi protein er (estrogen receptor) pada kanker payudara derajat keganasan baik, sedang dan buruk (protein expression er (estrogen receptor) in breast cancer degree of malignancy low, moderate, severe)

Author :

  1. Imam Susilo*1
  1. Departemen Patologi Anatomi, Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo

Abstract :

Introduction: Mammary carcinoma is the most common malignancy and main mortality cause in woman. Hormonal status (ER and PR expression) was long used as patient suitability for hormonal therapy. But lately there are many patients with ER and PR negative. Pada kesempatan ini, peneliti ingin membuktikan relevansi ekspresi protein ER (estrogen receptor) dengan derajat keganasan histopatologik kanker duktal invasif payudara dan prognosisnya antara kanker payudara dengan  ekspresi protein ER positif dan negatif. Method: In this retrospective and cross sectional analitical study, we retrieved data about hormonal status (ER expression) and histopathological grading of infiltrating ductal carcinoma patients. This study consisted of 201 patients with mammary carcinoma who referred to medical records Department Pathology Anatomic of Faculty Medicine Airlangga University / Dr. Soetomo General Hospital Surabaya on 1 January 2010-31 December 2010 and their medical record suitable with inclusion criterias. The data was catagorized in several groups based on ER expression result. Results: Most of the sample was in 41-50 years age group (37,31%), and 54,7% of them were in poor expression. The relationship of estrogen receptor (ER) with the degree of histopathology infiltrating ductal carcinoma patients, obtained p-value = 0.001 (p <0.5) and the 2x2 table is only moderate and severe degrees compared with the results of  ER expression results obtained p = 0.001 (p <0.5) and Odds ratio of 0.362 (CI: 0194-0675). Discussion: This study found significant correlation between ER expression with histopathological grading of infiltrating ductal carcinoma patients.  

Keyword :

infiltrating ductal carcinoma, ER expression, histopathological grading,


References :

Hess, RA,(2003) Estrogen in the adult male reproductive tract: A review - : Reproductive Biology and Endocrinology





Archive Article

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Volume : 7 / No. : 1 / Pub. : 2012-04
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  2. Peningkatan Self-care Agency Pasien Dengan Stroke Iskemik Setelah Penerapan Self-care Regulation Model (the Improvement Of The Self-care Agency For Patients With Ischemic Stroke After Applying Self–care Regulation Model In Nursing Care)
  3. Tingkat Kepatuhan Pasien Gagal Ginjal Kronik Dalam Pembatasan Cairan Pada Terapi Hemodialisa (the Compliance Chronic Renal Failure Patient On Restrictions Liquids In Hemodialysis Therapy)
  4. Konsep Diri, Dukungan Sosial Dan Kecemasan Menghadapi Keadaan Sakit Pada Pasien Fraktur (self-concept, Social Support, And Anxiety In Dealing With Fractured-patient)
  5. Faktor Risiko Timbulnya Diabetes Mellitus Pada Remaja Smu Di Kota Malang The Risk Factors Of Diabetes Mellitus In Adolescent High School In Malang City
  6. Mutu Asuhan Keperawatan Berdasarkan Analisis Kinerja Perawat Dan Kepuasan Perawat Dan Pasien (quality Of Nursing Care Based On Analysis Of Nursing Performance And Nurse And Patient Satisfaction)
  7. Model Adaptif Conservation (acm) Dalam Meningkatkan Dukungan Keluarga Dan Kepatuhan Berobat Pada Pasien Tb Paru Di Wilayah Kota Surabaya (adaptif Conservation (acm) Model In Increasing Family Support And Compliance Treatment In Patient With Pulonary Tuberculosis In Surabaya City Region)
  8. Pengembangan Model Peningkatan Kinerja Tenaga Keperawatan Dalam Penerapan Manajemen Terpadu Balita Sakit (mtbs) Di Surabaya (the Development Of Nursing Job Performance Model In The Implementation Of Integrated Management Of Childhood Illness (imci) In Surabaya)
  9. Peningkatan Kebersihan Diri Pada Pasien Halusinasi Dengan Pendekatan Metode Partisipatif Dan Rewards (the Increase Of Self Personal Hygiene Patient With Hallusination By Nursing Methods Of Partisipatif And Rewards Approach)
  10. Ekspresi Protein Er (estrogen Receptor) Pada Kanker Payudara Derajat Keganasan Baik, Sedang Dan Buruk (protein Expression Er (estrogen Receptor) In Breast Cancer Degree Of Malignancy Low, Moderate, Severe)
  11. The Increasing Of Preschool Multiple Intelligences By Educative Playing Instrument Stimulation