Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 2 / Published : 2009-12

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Original Article :

Aqueous humortransforming growth factor-e2 level in patients with and without posterior capsule opacity after congenital cataract surgery

Author :

  1. Imamatul Ibaroh*1
  2. Wasisdi Gunawan*2
  3. Retno Ekantini*3
  1. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta

Abstract :

Although microscopic operation technique improves pediatric cataract surgery results, posterior capsule opacification (PCO)remains the most common complication after congenital cataract surgery. Histology of PCO has been known, but the underlying cellularmechanisms remain unclear. Recently the role of cytokines present in the anterior segment after cataract surgery was investigated, suchas TGF-E2. TGF-Econtrols the differentiation of various types of cells.TGF-Ealso induces cataractogenesis. Laboratory studies showedthat in high level of TGF-E2, PCO occur more easily. The aim of this study is to determine the differences of aquoeus humor TGF-E2level in patients with and without posterior capsule opacity after congenital cataract surgery. The design of study was cross-sectional,and population target is all congenital cataracts that were underwent cataract surgery by using intraocular lens (IOL) in the bag,and without primary posterior curvilinear capsulorexis (PPCC) in Sarjito Hospital Yogyakarta and Dr Yap Eye Hospital Yogyakarta.This study revealed mean TGF-E2 level in the group with PCO was 259.91 (± 63.45) pg/ml and in the group without PCO was 225.81(± 121.26) pg/ml. The difference of TGFE2 level in the group with PCO and without PCO is not significant

Keyword :

congenital cataract, PCO, TGF-B2,

References :

Rahi JS and Dezateux C,(2000) Congenital and infantile cataract in the United Kingdom: underlying or associated factors - : British Congenital Cataract Interest Group Organization - Invest Ophthalmol Vis Sci

Apple D.J., Peng Q., and Vissessook N,(2001) Eradication of Posterior Capsule Opacification - : Ophthalmology

Wilson, Jr., M.E.; Trivedi, Rupal H.; Pandey, and Suresh K,(2005) Pediatric Cataract Surgery: Techniques, Complications, and Management - : Lippincott Williams & Wilkins (LWW)

Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2009-12
  1. The Comparison Of Active And Total Transforming Growth Factor-e2 Concentration On Fresh And Cryopreservation Amnion Membrane
  2. Aqueous Humortransforming Growth Factor-e2 Level In Patients With And Without Posterior Capsule Opacity After Congenital Cataract Surgery
  3. Surgical Result Of Pseudophakic Retinal Detachment In Cikini Hospital-school Of Medicine Christian University Of Indonesia Jakarta
  4. The Effectiveness Of Lipofilm Microemulsion Eye Drops In Dry Eye Syndrome By Enhancing The Tear Film Quality
  5. The Difference Between Total And Active Transforming Growth Factor E2 Concentration On Fresh And Freeze-dried Amnion Membrane (laboratory Experimental Study In Dr. Soetomo General Hospital Surabaya)
  6. Management Of Upper Eyelid Coloboma With Three Steps Technique Surgery
  7. Bilateral Papil Atrophy In A Case With Intracerebellar Tuberculoma