Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 5 / No. 3 / Published : 2007-12

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Original Article :

C y t o k i n e s

Author :

  1. Admadi Soeroso*1
  1. Bag./Lab. Ilmu Penyakit Mata Fakultas Kedokteran Universitas Negeri Sebelas Maret / RSUD Dr. Moewardi, Jl. Kolonel Sutanto No. 132 Surakarta

Abstract :

Many critical interactions among cells of the immune system are controlled by soluble mediators called cytokines. These cytokines are a diverse group of intercellular signaling peptides and glycoproteins with low molecular weights and most of them are genetically and structurally unrelated to one another. Several hundred have been identified to date. Each is secreted by particular cell types in response to a variety stimuli and produces characteristic effects on the growth, mobility, differentiation, or function of target cells. Collectivelly, they regulate not only immune and inflammatory responses but also wound healing, hematopoiesis, angiogenesis, and many other biologic processes. They are extremely potent compound that act at slight concentrations by binding to specific surface receptors on target cells. Unlike endocrine hormones, they are not produced by specialized glands and secreted into the circulation, but rather are produced locally by a variety of tissues and cells. Only a few cytokines, such as transforming growth factor beta, erythropoietin, stem cell factor (SCF), monocyte colony-stimulating factor (M-CSF), are normally present in detectable amounts in the blood and are able to influence distant target cells. Most other cytokines, unless produced in excess, act only locally over short distances, in either a paracrine manner (ie, on adjacent cells) or an autocrine manner (ie, on producing cell itself).

Keyword :

cytokines ,

References :

I Handoyo,(2003) Pengantar imunoasai dasar, cetakan pertama Surabaya Indonesia : Airlangga University Press

Archive Article

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Volume : 5 / No. : 3 / Pub. : 2008-12
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