UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 8 / No. 1 / Published : 2011-12

Order : 2, and page :6 - 10

Related with : Scholar   Yahoo!   Bing

Original Article :

Difference expression of matrix metalloproteinase-1 (mmp-1) in primary progressive pterygium after subconjunctival injection of mitomycin c and 5-fluorouracil

Author :

  1. Ayu S. Oetoyo*1
  2. Suhardjo*2
  3. Agus Supartoto*3
  1. Department of Ophthalmology, Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta
  2. Department of Ophthalmology, Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta
  3. Department of Ophthalmology, Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta

Abstract :

The purpose of this study was to compare the expression of matrix metalloproteinase-1 in primary pterygium aftermitomycin C and 5-Fluorouracil subconjunctival injection. This is a cross sectional study. There were 54 subjects included,divided into 2 groups, mitomycin C group (n = 27) and 5-Fluorour acil group (n = 27), were injected a week before incision.Fivetyfour formalin-fixed, paraffin-embedded of the pterygium tissue were enrolled in this study. Those samples wereanalyzed immunohistochemically, with MMP-1 monoclonal antibody (IM 135L) to determine the expression of MMP-1.The Results of this study showed, the expression of MMP -1 in mitomycin C group was 13.22 ± 12.59 and 5-Fluorouracil group was12,00 ± 7. There were no statistically signifficant differences between those two groups with P > 0.05 (p = 0.669, Mann-Whitney test).The baseline characteristic between the two groups was similar. In conclusion the use of antiproliferation and antifibrotic agents suchas mitomycin C and 5-fluorourasil as an adjuvant therapy can give some influence in the expression of MMP-1.

Keyword :

MMP-1 expression, primary pterygium, mitomycin C, 5-Fluorouracil,


References :

  1. Tan D.H. , (2002). Pterigium, Ocular Surface Disease. 65 91. 13 : Medical and Surgical Managemant. Springer-Verlag New York Inc
  2. Li D.Q., Lee S.B., Gunja S.Z., Liu Y.Q., Solomon A., Meller D, (2001). Overexpressionof collagenase (MMP-1) and tromelysin (MMP-3) by pterygium headfibroblast. 119 (1): 71–80 : Arch Ophthalmol
  3. Duskhu N., John M., Schultz GS., Reid T.W, (2001). Pterygia Pathogenesis: Corneal Invasion by Matrix Metalloproteinase Expressing Altered Limbal Epithelial Basal Cells. 119 (5): 695–706 : Arch ophthalmol




Archive Article

Cover Media Content

Volume : 8 / No. : 1 / Pub. : 2011-12
  1. The effect of altitude exposure to changes in intra ocular pressure in air force pilot candidates using hypobaric chamber
  2. Difference expression of matrix metalloproteinase-1 (mmp-1) in primary progressive pterygium after subconjunctival injection of mitomycin c and 5-fluorouracil
  3. Time length difference of examination between waggoner (color vision testing made easy) and ishihara in children under 6 years old
  4. Ketebalan kornea sentral pada penderita diabetes mellitus tipe 2 sebelum dan setelah fakoemulsifikasi
  5. Perbedaan ketebalan kornea sentral pada glaukoma sudut terbuka primer, glaukoma dengan tekanan normal dan hipertensi okuli
  6. Changes in tear film after temporal clear corneal incision phacoemulsification
  7. Rectus muscles transposition for the treatment of bilateral traumatic abduscens palsy
  8. Congenital left superior oblique palsy
  9. Congenital bilateral sixth nerve palsy
  10. Penanganan benda asing peluru dalam kavum orbita