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Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 3 / Published : 2010-06

TOC : 5, and page :106 - 109

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Original Article :

Perbandingan ekspresi p53 pada pterigium primer progresif setelah pemberian injeksi subkonjungtiva dengan mitomicin c dan 5 fluorourasil

Author :

  1. Santi Anugrahsari*1
  2. Wasisdi Gunawan*2
  3. Suhardjo*3
  1. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta

Abstract :

The aim of this study is to determine the expression ratio of p53 in primary progressive pterygium after subconjunctival injectionof Mitomicin C and 5 fluorouracil. This study is quasi experimental with posttest only design, performed at Sardjito Hospital and itsnetworks, are regrouped into 2 groups with injection treatment subconjunctival mitomicin C or 5-FU 1 week before surgery. Tissuestored in buffered formalin, staining with the monoclonal antibody DO-7, mutant p53 expression is calculated per100cells, in 5 field ofview, 400x magnification. There were 53 subjects, 27 specimens in MMC group and 26 specimens of group 5 FU. Not found significantdifferences in the characteristics of subjects. In this study, the expression in p53 of MMC groups was 5.71 ±1.83, and in 5FU groupwas 10.29 + 4.54 (p = 0.000). Variable age showed a significant correlation of 0.29 and the average influence p53 expression. Themean expression of p53 in group Mitomicin C group lower than 5Fluorouracil group

Keyword :

primary progressive pterygium, mutant p53, mitomicin C, 5 fluorouracil, immunohistochemistry,


References :

  1. Assia E, (2002). Surgical management of pterygium. - : IMAJ
  2. Shimmura S, Ishioka M, Hanada K, Shimazaki J, Tsubota K, (2000). Telomerase activity and p53 expression in pterygia. - : Investigative Ophthalmol & Vis Science
  3. Nasiri MRG, Rezaei E, Ghafarzadegan K, Toosi MS, Malekifard, (2007). Expression of p53 in colorectal carcinoma: correlation with clinicopathologic features. - : Arch Iran Med


   


Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2010-06
  1. Effect of genistein on conjunctival goblet cells density and the expression of interleukin-1bin ovariectomized rats
  2. The relation of onset of trauma and visual acuity on traumatic patient
  3. The role of human papilloma virus type 16 in retinoblastoma
  4. Ocular survival rate penderita retinoblastoma yang telah dilakukan enukleasi atau eksenterasi di rsud dr. soetomo surabaya
  5. Human papilloma virus in progressive pterygium and stationary pterygium
  6. Perbandingan ekspresi p53 pada pterigium primer progresif setelah pemberian injeksi subkonjungtiva dengan mitomicin c dan 5 fluorourasil
  7. Effect of genistein on conjunctival goblet cells density and the expression of interleukin-1b in ovariectomized rats
  8. Management of upper eyelid coloboma with three steps technique surgery
  9. Ptotic management in marcus gunn jaw-winking syndrome
  10. The Caterpillars Eat One Eye On The Pseudo Lymphoma Tumor
  11. The untreatable case of retinopathy of prematurity grade v