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Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 1 / Published : 2009-06

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Original Article :

The different p5353 expressions of basal cell carcinoma and squamous cell carcinoma in the periocular skin area

Author :

  1. Kalqin Alimi Qomara*1
  2. Hartono*2
  3. Retno Ekantini*3
  4. Agus Supartoto*4
  1. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta
  2. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta
  3. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta
  4. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta

Abstract :

The aim of this study is to compare the expression of p53 in the basal cell carcinoma and squamous cell carcinoma. A total of28 tissues from 14 tissues basal cell carcinoma and 14 tissues squamous cell carcinoma were collected and examined. Expressions of p53 in the two groups were detected imuohistochemically by DO–7 monoclonal antibody. The p53 expressions were counted for positive cells per 100 cells in five different areas. The positive expression was stronger and higher in squamous cell carcinoma than that in basal cell carcinoma. The difference was significant (P < 0.05), whereas the expression of p53 in basal cell carcinoma was 20.0 ± 13.4 per 100 cells and in squamous cells carcinoma was 42.4 ± 28.9 per 100 cells. The expression of p53 in squamous cell carcinoma was higher than that in basal cell carcinoma and the difference was statistically significant.

Keyword :

basal cell carcinoma, squamous cell carcinoma, p53,


References :

  1. Asher G, Lotem J, Sachs L, Kahana C, Shaul Y, (2002). Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. - : Proc Natl Acad Sci USA
  2. Auepemkiate S, Boonyaphiphat P, Thongsukai P, (2002). P53 Ekspression Related to The Aggressive Infiltrative Histopathological Feature of Basal Cell Carcinoma. - : Histopathology
  3. Bactinac T, Zamolo G, Jonjic N, Gruber F, (2003). Petrovecki M. P35 Protein Ekspresion and Proliferation in Non-Neoplastic and Proloferative Skin Disease. - : Tumori


   


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