UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 2 / Published : 2009-12

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Original Article :

The effectiveness of lipofilm microemulsion eye drops in dry eye syndrome by enhancing the tear film quality

Author :

  1. Henry Warouw*1
  2. Retno Ekantini*2
  3. Tri Wahyu Widayanti*3
  1. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta

Abstract :

The aim of this study was to evaluate the effectiveness of lipofilm microemulsion as ocular lubricant in dry eye syndrome. It wasprospective randomized clinical trial design with single blind masked study. Sixty eyes were enrolled according to the inclusion andexclusion criteria. Two weeks and four weeks of follow-up were documented. Objective parameters were Schirmer I test and break uptime test. Subjective symptoms were assessed by means of 1-10 scale of visual analogic score. Thirty eyes were enrolled to lipofilmgroup and 30 eyes to sodium hyaluronate 0.15% group. Both groups had improvement in mean Schirmer test (p < 0.001) but therewas no statistically difference between two groups after two weeks (p = 0.361) and four weeks (p = 0.081). Both groups induced asignificant increase of break up time test (p < 0.001) and there was statistically significant difference in lipofilm group after two weeks(p = 0.037) and four weeks (p = 0.002). Symptoms improved in all groups but statistically significant different in lipofilm group inforeign body sensation (p = 0.001) and blurred vision (p = 0.021) after two weeks. Lipofilm tends to show a faster improvement thansodium hyaluronate in patients with dry eye syndrome

Keyword :

lipofilm microemulsion, sodium hyaluronate, Schirmer test, break up time test, visual analogic score, dry eye syndrome,


References :

2007 Report of the International Dry Eye Workshop (DEWS),(2007) The Ocular Surface - : -

Calonge M,(2001) The treatment of dry eye - : Surv Ophthalmol45

Johnson, M.E., Murphy, P.J,(2004) Changes In The Tears Film and Ocular Surface From Dry Eye Syndrome - : In Progress in Retinal and Eye Research





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2009-12
  1. The Comparison Of Active And Total Transforming Growth Factor-e2 Concentration On Fresh And Cryopreservation Amnion Membrane
  2. Aqueous Humortransforming Growth Factor-e2 Level In Patients With And Without Posterior Capsule Opacity After Congenital Cataract Surgery
  3. Surgical Result Of Pseudophakic Retinal Detachment In Cikini Hospital-school Of Medicine Christian University Of Indonesia Jakarta
  4. The Effectiveness Of Lipofilm Microemulsion Eye Drops In Dry Eye Syndrome By Enhancing The Tear Film Quality
  5. The Difference Between Total And Active Transforming Growth Factor E2 Concentration On Fresh And Freeze-dried Amnion Membrane (laboratory Experimental Study In Dr. Soetomo General Hospital Surabaya)
  6. Management Of Upper Eyelid Coloboma With Three Steps Technique Surgery
  7. Bilateral Papil Atrophy In A Case With Intracerebellar Tuberculoma

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