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Jurnal Penelitian Medika Eksakta

ISSN 1411-6626

Vol. 2 / No. 1 / Published : 2001-04

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Original Article :

Quality assessment of marketed glibenclamide 5 mg tablets

Author :

      Abstract :

      The objective of this study is to identify the quality of marketed glibenclamide tablets of 5 mg using content homogeneity and dissolution efficiency parameters. This research was carried out on products of six pharmaceutical industries namely by coding was PMA products (A, B), PMDN products (C, D), Generic products (E, F) and innovator A as a selected standard. Referring to Farmakope Indonesia 4th edition 1995 procedure, the content homogenity content was determined, whereas dissolution assessment was used paddle method with phosphate buffer pH 7.4 as media . The result of content homogeneity analyses showed that A, B, and F products meet the standard requirement; as in contrast to C, D and E products that exceded for the standard requirement. Dissolution assessment data revealed there were significantly different in the dissolution profile between the five products compared to A. The deviation of dissolved glibenclamide in 90 minutes (ED90) B, C, D, E, and F compared with A is -7.06%, -45.67%, -46.99%, +26.99%, +20.97%, respectively. Statistical analysis ( = 0.05) for ED90 value showed the significantly different of ED90 between five products compared with A. In conclusion there was significantly different of quality of glibenclamide 5 mg products.

      Keyword :

      glibenclamide, dissolution, quality product-safety,


      References :



           


        Archive Article

        Cover Media Content

        Volume : 2 / No. : 1 / Pub. : 2001-04
        1. Reducing The Toxic Of Heavy Metal Lead Pollutant By The Wood Particle Of Cinnamomum Camphora
        2. Quality Assessment Of Marketed Glibenclamide 5 Mg Tablets
        3. Utilization Of Total Alkaloides From The Stem Bark Of Sccopetalum Harsiedtii As Biolarvacide
        4. The Diversity And Character Visualization Of Associative Fungi With Liter Degradation Process In Mangrove Enviroment
        5. Detection Of Lyzozyme Activity Of Kakap Merah Lutjanus Sp Which Have Bactericidal Activity
        6. The Preliminary Study On Labotory Test Inactive Vaccine Production Of S.pullorum Against Post Vacinal Antybody Titre Method
        7. Vitrification As An Alternative Storage Of Dairy Catle’s Semen
        8. The Prospect Of Carica Papaya Leaves On Increasing Feed Consumption, Egg Production And Egg Yolk In Local Hen
        9. The In Vitro Study Of Antiproliferatives Infussion ‘benalu Duku’ Against Cancer Cell (myeloma Cell)