Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)
ISSN 0852-1050
Vol. 6 / No. 2 / Published : 2008-10
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Original Article :
Influence of sorbitan monostearate on characteristics of salbutamol sulphate containing ethylcellulose microcapsules
Author :
Abstract :
Ethyl cellulose microcapsule containing salbutamol sulphate was prepared by double emulsion (water-in-oil-in-water) solvent evaporation method. The objective of this study was to investigate the influence of sorbitan monostearate as emulsifier of water-in-oil emulsion (primary emulsion) on the characteristics of microcapsule. Sorbitan monostearate was used on concentration of 1-3% w/v from volume of the oil phase. The particle size of microcapsule decrease with increasing of the sorbitan monostearate concentration. The shape evaluation shown that using sorbitan monostearate as emulsifier on primary emulsion yield an open microcapsule. The encapsulation efficiency decrease with increasing sorbitan monostearate concentration. The result for encapsulation efficiency study seems to be related to the shape of microcapsule.
Keyword :
salbutamol sulphate, ethyl cellulose, sorbitan monostearate, microcapsule,
References :
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Volume : 6 / No. : 2 / Pub. : 2008-10 |
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