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Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 2 / Published : 2009-10

TOC : 5, and page :25 - 30

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Original Article :

Pengaruh lama pemanasan pada sintesis 2-[2-(4-metoksi-fenil)-vinil]-benzo[1.3]oxazin-4-on

Author :

  1. Kholis Amalia Nofianti*1
  2. Juni Ekowati*2
  3. I Gde Nyoman Astika*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

The aim of this research is to compare percentage yield of  2-[2-(4-methoxyphenyl)-vinyl]-benzo[1,3]oxazin-4-one which  reaction time was 1 hour, 3 hours, and 6 hours, using  anthranilic acid and p-methoxycinnamoyl chloride as starting material and benzene as solvent  under temprature of ± 80-90º C. The products  were identified using TLC and melting point determination, UV-Vis spectrophotometry, IR spectrophotometry, 1H-NMR spectrometry inform that the product appropriate with structure of  2-[2-(4-methoxyphenyl)-vinyl]-benzo[1,3]oxazin-4-one. The percentage yield of product from the above reaction are 9.20%; 20.19%; and 21.57% yield for 1 hour, 3 hours, and 6 hours, respectively. The statistical analysis inform that there is no significant difference percentage yield between 3 hours and 6 hours reaction time. And there is significant difference percentage yield between 1 hour and two other reaction time.

Keyword :

Benzoxazin, Reaction Time, Yield Percentage,


References :

  1. Pine,H., Hendrickson, S.B.J.,Donald, J.,Geroge, S.,1988, (1988). Kimia Organik. Ed. IV pp 21-24 : Institut Tekhnologi Bandung
  2. Shariat , M. and Abdollahi, S, (2004). Synthesis of Benzoksazinone Derivats : A New Route to 2-(N-phtaloylmotil)-4H-3,1-Benzoksazin-4-one. No. 9 pp 705-712 : Molecules
  3. Rosemarie, F and Hanson, R.S.D, (2006). Kinetics and Mechanism of The Addition of Nucleophiles to α, β Unsaturated Thiol Ester. 71 pp. 6342-6350 : JOC Article.


   


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Volume : 7 / No. : 2 / Pub. : 2009-10
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