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Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 3 / No. 1 / Published : 2003-04

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Original Article :

Pengaruh pereaksi terhadap reaksi isomerisasi 4-alil-1,2-metilendioksibenzena hasil isolasi dari cinnamomum culliawan bl

Author :

  1. Sanusi Gugule*1
  2. GN. Astika*2
  3. Hadi Poerwono*3
  4. Soemadi*4
  1. FMIPA Universitas Negeri Manado
  2. Fakultas Farmasi Universitas Airlangga
  3. Fakultas Farmasi Universitas Airlangga
  4. Fakultas Farmasi Universitas Airlangga

Abstract :

The research have been made to find out the effect of reagent towards percentage of isomerization product of 4-alil-1,2-methylenedioxybenzene obtained by Cinnamomum cullilawan, BL. The isolation product of 4-alil-1,2-methylenedioxybenzene from Cinnamomum cullilawan, BL. is 7.05% yield. Then, such compound is isomerized to become isosafrole by means of t-BuOK/DMSO, KOH/n-BuOH, KOH/CH2OHCH2OH, NaOH/CH2OHCH2OH, KOH/C2H5OH. The Result of study shows that reagent t-BuOK/DMSO yields the highest product percentage, that is 97% (isosafrole). Isomerization is mostly affected by cation, anion, solvent and reaction condition. .

Keyword :

Cinnamomum cullilawan, BL., 4-alil-1, 2-methylenedioxybenzene, isosafrole, isomerization,


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