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Media Gizi Indonesia

ISSN 1693-7228

Vol. 2 / No. 3 / Published : 2006-08

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Original Article :

The influences of vitamin a and zinc-copper supplementation on response of iron supplemenaion among anaemic women

Author :

  1. Ikeu Ekayanti*1
  2. Bambang Wirjatmadi*2
  1. Staf Pengajar Gizi Masyarakat, FEMA, IPB, Bogor
  2. Staf Pengajar Fakultas Kesehatan Masyarakat Unair

Abstract :

Prevalence of iron deficiency anaemia is still high in Indonesia, especialy among reproductive–age women. The objective of this study was to investigate the influence of vitamin A and Zinc-copper administration on response of iron supplementation in anaemic women. This Nested-Case Control Study was undertaken for 8 weeks using pre test and post test control group design. Population consisted of 250 female workers (reproductive age) in P.T. Sekar Laut , Sidoarjo, province of East Java. The samples were 83 subject, which were divided into three groups, i,e, group P1 that received only iron, group P2 that received iron and vitamin A and group P3 that received iron and combination vitamin A with zinc-copper. Results showed highly significant difference of Hb; Hb increase level; proportion in increasing Hb level; serum iron; proportion in increasing serum iron level; and ferritin increase level in pre test and post test each group with p value in all group showed P < 0,05 . The difference of Hb level was found to increase from group P1 that received iron supplement only (11,55 ± 1,66 g/dl), to group P2 that received iron and vitamin A ( 12,26 ± 1,40 g/dl) and finally group P3 that received iron and combination vitamin A with Zinc-copper (12,94 ± 1,05 g/dl). Post test Hb level between groups showed significant difference with p=0,002. Significant difference in Hb level was found only between group P1 and group P3. However, significant difference in Hb increase level was found not only between group P1 and group P2 (p= 0,012), but also between group P1 and group P3 (p= 0,000). The difference of serum iron was found increase from group P1 (80,86 ± 18,76 μg/dl) , to group P2 ( 87,55 ± 30,88 μg/dl) and finally to group P3 (105,61 ± 35,19 μg/dl). Post test serum iron level between group showed significant difference with p= 0,009. Significant difference in serum iron level was found between group P1 and group P3 (p= 0,004), and between group P2 and group P3 (p= 0,021). Post test of ferritin increase level between group P2 (1,41 ± 14,28 ng/ml)and group P3 (6,33 ±21,24 ng/ml) showed significant difference with p=0,045. In view of numerous positive aspects in this study, a program to provide vitamin A, Zinc, copper and iron supplement for anaemic women is worth consider.

Keyword :

anaemic women, vitamin A, zinc-copper, response of iron supplementation ,


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