UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 6 / No. 1 / Published : 2006-10

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Original Article :

Dehydroepiandrosterone (dhea) and intracrinology

Author :

  1. Paulus Liben*1
  2. Paulus Liben*2

Abstract :

Dehydroepiandrosterone (DHEA) is a prohormone secreted in large amounts by the adrenals in humans. It is secreted in larger quantities than cortisol and is present in the blood at concentrations only second to cholesterol. DHEA is transformed into androgens and/or estrogens in peripheral target tissues, thus permitting all androgen-sensitive and estrogen-sensitive tissues to make locally and control the intracellular levels of sex steroids according to local needs. This new field of endocrinology has been called intracrinology. In women, after menopause, all estrogens and almost all androgens are made locally in peripheral tissues from DHEA which indirectly exerts effects, among others, on bone formation, adiposity, muscle, insulin and glucose metabolism, skin, libido and well-being. In men, where the secretion of androgens by the testicles continues for life, the contribution of DHEA to androgens has been best evaluated in the prostate where about 50% of androgens are made locally from DHEA. The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women’s health at menopause.

Keyword :

intracrinology, DHEA, androgens, estrogens, menopause,


References :

WF Boron,(2005) Medical physiology. A cellular and molecular approach. Updated ed. Philadelphia : Elsevier Saunders

E Boulpaep,(2005) Medical physiology. A cellular and molecular approach. Updated ed. Philadelphia : Elsevier Saunders

WF Ganong,(2005) Review of medical physiology. 22nd ed. New York : McGraw Hill

AC Guyton,(2006) Textbook of medical physiology. 11th ed. Philadelphia : WB Saunders Co,

JE Hall,(2006) Textbook of medical physiology. 11th ed. Philadelphia : WB Saunders Co,

F Labrie,(2005) Is dehydroepiandrosterone a hormone? - : J of Endocrin 187

The V Luu,(2005) Is dehydroepiandrosterone a hormone? - : J of Endocrin 187

A Belanger,(2005) Is dehydroepiandrosterone a hormone? - : J of Endocrin 187

SX Lin,(2005) Is dehydroepiandrosterone a hormone? - : J of Endocrin 187

J Simand,(2005) Is dehydroepiandrosterone a hormone? - : J of Endocrin 187

G Pelletier,(2005) Is dehydroepiandrosterone a hormone? - : J of E



Archive Article

Cover Media Content

Volume : 6 / No. : 1 / Pub. : 2006-10
  1. Beda Efek Pemberian Epinefrin Akut Dan Kronis Terhadap Mcv Pada Tikus Putih Jantan(rattus Norvegicus) Strain Wistar
  2. Dehydroepiandrosterone (dhea) And Intracrinology
  3. Pengaruh Latihan Aerobik Gelombang Progresif Terhadap Kadar Lemak Tubuh Dan Kebugaran Aerobik Pada Penderita Overweight
  4. Moderate Compare With Low Intensity Combo Dance In Women Fitness Index
  5. Roles Of Autonomic Nerves In Heart Rate Regulation
  6. Aspek Fisiologis Pertahanan Tubuh Udang Windu (penaeus Monodon) Terinfeksi White Spot Baculo Virus (wsbv) Yang Diberikan Protein Imunogenik Vp28
  7. Uji Signifikansi Statistik: Konstroversi Dan Usulan Solusi

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