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Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 8 / No. 1 / Published : 2008-10

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Original Article :

Efek dari rebusan daun tembakau kering terhadap blood platelet count dan prothrombin time pada strain wistartikus putih (rattus norvegicus)

Author :

  1. Fahrun Nur Rosyid*1
  2. Tjitra Wardani*2
  1. Fakultas Ilmu Kesehatan Universitas Muhammadiyah Surabaya
    Jl. Sutorejo No 59 Surabaya
  2. Departemen Ilmu Faal
    Fakultas Kedokteran Universitas Airlangga Surabaya
    Jl. Mayjen.Prof.dr.Moestopo No.47 Surabaya

Abstract :

Nicotine that presents in dry tobacco leaf is also able to mobilize compartment platelet through symphatetic activity that results in the increase of blood platelet count (thrombocytosis). The objective of this study was to prove the effect of nicotine in dry tobacco leaf on blood platelet count and prothrombin time. This study used separate sample pretest-posttest control group design, involving male Wistar strain Rattus norvegicus aged of 3 - 3.5 months. The independent variable was dry tobacco leaf boiled (0.6 ml/200 mg rats BW) and the dependent variables were blood platelet count (/µl) and prothrombin time (second). Pretest data were taken from control group and posttest data were dry tobacco leaf boiled for 5 days. The results showed that in dependent variable of blood platelet count, there was significant difference between control group and group receiving dry tobacco boiled (p : 0.000). In the variable of prothrombin time, there was no difference between control group and group receiving dry tobacco leaf boiled (p : 0.200). The result indicated that the provision of dry tobacco leaf boiled was able to increase blood platelet count and did not increase prothrombin time.

Keyword :

Dry tobacco leaf boiled, blood platelet count, and prothrombin time

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References :

  1. Becker WM, Reece JB, Poenie MF, (1999). The World of The Cell. 3rd ED., pp.278-288 : The Benjamin/Cumming Publi Com, California,


   


Archive Article

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Volume : 8 / No. : 1 / Pub. : 2008-10
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