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Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 5 / No. 2 / Published : 2006-02

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Original Article :

Pengaruh curcumin terhadap kekuatan kontraksi jantung tikus betina yang diperlakukan iskemia – reperfusi dengan metode langendorff

Author :

  1. Muhammad Rusydi*1

Abstract :

Ischemia reperfussion is a phenomenon in which an ischemic area is suddenly revascularized. Myocard ischemia occurs due to imbalanced demand and supply of oxygen in heart muscle, resulting in the production of free radicals that may damage cells and disturb heart muscle contractility. The latter may reduce stroke volume, which in turn reduce the cardiac-output. As a compensation, heart contraction frequency and force is increasing abnormally. The adverse effect of ischemia reperfussion can be alleviated by providing antioxidants. Curcumin is one of strong antioxidants as it has a capability as ROS scavenger. This study used female mice which had estrogen, one of cardiac protective elements with antioxidative nature. The objective of this study was to observe the effect of curcumin on heart contractility in female mice subjected to ischemia reperfussion, whether the contractility increased, decreased or neutral after being interacted with endogeneous estrogen. The experimental animals were given with curcumin of 100, 200, and 400 mg/kgbw for 7 days and subjected to ischemia for 30 minutes and reperfussion for 10 minutes using Langendorff method. Heart contractility was observed in situ using Rikadenki recorder. This study used complete randomized design. The results showed that reduced heart contractility force, particularly in low dose curcumin (100 mg/kgbw) and increased again in higher dose. However, the contractility reduction was not significant (p < 0.05) since the reduction only represented curcumin control over heart muscle contractility that was being compensated due to free radicals after ischemia reperfussion.

Keyword :

ischemia reperfussion, curcumin, heart muscle contractility,


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Archive Article

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