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Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 7 / No. 1 / Published : 2007-10

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Original Article :

Perubahan gustducin dan neutrofil pada keadaan demam

Author :

  1. Jenny Sunariani*1
  1. Departemen Biologi Oral, Fakultas Kedokteran Gigi Universitas Airlangga
    Jl. Mayjen Prof. Dr. Moestopo No. 47 Surabaya 60132 Indonesia

Abstract :

Homeostatic changes in the body, such as fever, may cause a sense of bitterness in the mouth. It implies in the reduction of appetite, which may finally result in the reduction of physical condition due to inadequacy of food intake. It causes the inhibition of healing process, which reduces working productivity. The objective of this study was to identify the mechanism of bitterness due to inflammation, as proved locally in the taste buds of Wistar rats. This study was carried out experimentally using post-only control design in experimental animals of male Wistar strain Rattus Norvegicus. The animals were divided into two groups: first group served as control, while the second received treatment with Salmonella thypimurium 0.5 ml/kgBW. Tongue incision was taken from the animals for neutrophyl examination and immunohystochemical staining for the variables Gustducin. Data were analyzed using Leven's test to determine sample homogeneity, Kolmogorov-Smirnov test for data normality, and comparative test. From the result, it was found that there was an increase of biological response of signaling transduction of bitterness in taste buds, as indicated from the increase of the amout of gustducin and neutrofil. The result is there is significance different in treatment group or in inflammatory fever condition compared to control group (p < 0.05). By unfolding its mechanism, further studies can be recommended to find the way to inhibit this sense of bitterness. The results are intended to overcome homeostatic disorder in the body to prevent loss of appetite, so that physical endurance can be maintained.

Keyword :

inflammation, taste buds, gustducin,


References :



       


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