Majalah Ilmu Faal Indonesia
ISSN 0215-1995
Vol. 9 / No. 3 / Published : 2010-06
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Original Article :
The improvement of high density lipoprotein level in rats (rattus norvegicus) with high fat diet and black soybean supplementation
Author :
- Retno Widiastutik*1
- Fakultas Kedokteran Hewan Universitas Airlangga Jl. Mulyorejo (Kampus C Unair)
Abstract :
Prevalence of vascular atherosclerosis in Indonesia was improving, not only in human but also in animal. The most important cause of this disease is high cholesterol blood level. The aim of this study was to know effect of black soybean supplementation to HDL level in rat induced by high fat diet. Twenty four male white Wistar rats (Rattus norvegicus) divided into three groups randomly, were given high fat diet to induce hypercholesterolemia condition. The first group (P0) was given high fat diet and aquadest treatment, the second group (P1) was given high fat diet and black soybean milk feeding, and the third group (P2) was given standard diet and black soybean milk feeding. Hypercholesterolemia condition was gained after feeding high fat diet content for 4 weeks proceed with 3 weeks black soybean supplementation. The blood was taken out intracardial and then HDL level in blood serum was measured. Data analyzed by Analysis of Variant (Anova).The result showed HDL blood serum level in P0 was 20.88 ±1.246; P1 was 28.00±2.726; and P2 was 25.38±2.504, which was different significantly between group P0 and P1,P2 (p<0,05), but not in P1 and P2 . In conclusion, black soybean milk feeding has increasing HDL blood serum level of the rats.
Keyword :
Black soybean milk, high fat diet, high density lipoprotein,
References :
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Volume : 9 / No. : 3 / Pub. : 2010-06 |
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