Media Kedokteran Hewan
ISSN 2015-8930
Vol. 26 / No. 2 / Published : 2010-05
Order : 3, and page :128 - 133
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Original Article :
Antiproliferation effect of the n-hexanal extract of kesum (polygonum minus) at the cells of the rat lung cancer effort exploiting of kesum as drug of lung cancer
Author :
- Muhamad Agus Wibowo*1
- Aulanni’am*2
- Farid Rahman*3
- M. Sofwan Anwari*4
- Chemistry Department, Science Faculty of Tanjungpura University, Pontianak, Indonesia
- Chemistry Department, Faculty of Science, Brawijaya University, Malang, Jl. Veteran, Malang, Indonesia
- Chemistry Department, Faculty of Science, Brawijaya University
- Chemistry Department, Science Faculty of Tanjungpura University, Pontianak, Indonesia
Abstract :
Kesum (Polygonum minus) is used to make typical foods by the peoples in the West Borneo, because of delicious in taste and aroma. It contains 6,7-methylenedioxy-5,3’,4’,5’-tetramethoxyflavone and 6,7-4’,5’-dimethylene-dioxy-3,5,3’-trimethoxyflavone compounds, and high of phenolics compounds. Kesum has the potency of anticancer activity and it can be used to prevent development of cancers cells. This research has been tasted of anti proliferation activity of the n-hexane extract of kesum to the animal model of lung cancer. Confirmation of proliferation activity is conducted by PCNA staining. Results of research indicated that the extract of n-hexane can reduce proliferation activity of the lung cells of the animal models.
Keyword :
Kesum, Polygonum minus, anti proliferation,
References :
Aklillu E, Ovrebo S, Botnen IV, Otter C, and Ingelman-Sundberg M.,(2005) Characterization of Common CYP1B1 Variants with Different Capacity for Benzo[a]pyrene-7,8-Dihydrodiol Epoxide For-mation from Benzo[a]pyrene 65(12): 5105-5111 : Cancer Res
Ariese F, Small GJ, and Jankowiak R,(1996) Confor-mational studies of depurinating DNA adducts from syn-dibenzo[a,r|pyreiie diolepoxide. Carcinogenesis 17(4): 829-837 : -
Belous AR, Hachey DL, Dawling S, Roodi N, and Parl FF,(2007) Cytochrome P450 1B1–Mediated Estrogen Metabolism Results in Estrogen-Deoxyribonucleoside Adduct Formation.Cancer Res 67(2): 812–817 : -
Huda-Faujan N, Noriham A, Norrakiah AS and Babji AS,(2007) Antioxidative Activities of Water Extracts of Some Malaysian Herbs. Asean Food J 14 (1): 61-68 : -
Hwang IK, Yoo K-Y, Kim DW, Jeong SJ, Won CK, Moon W-K, Kim YS, Kwon DY, Won MH, and Kim DW,(2006) An extract of Polygonummultiflorum protects against free radical damage induced by ultraviolet B i
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Volume : 26 / No. : 2 / Pub. : 2010-05 |
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