UNIVERSITAS AIRLANGGA



Detail Article

Media Kedokteran Hewan

ISSN 2015-8930

Vol. 30 / No. 1 / Published : 2014-01

Order : 3, and page :29 - 41

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Original Article :

Radiological evaluation of femoral fractures healing in male rat with cissus quadrangularis extract

Author :

  1. Ira Sari Yudaniayanti*1
  2. Bambang Sektiari L*2
  3. Djoko Galijono*3
  1. Dosen Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Abstrak Penelitian ini bertujuan untuk membandingkan  antara pengaruh pemberian suplemen kalsium karbonat dengan Cissus quadrangularis (CQ) dalam mempercepat proses kesembuhan patah tulang femur pada tikus berdasarkan gambaran radiografi. Penelitian ini menggunakan 18 ekor tikus putih jantan (Rattus Norwegicus) umur 12 minggu. Setelah 1 minggu diadaptasikan, semua tikus dilakukan operasi reposisi patah tulang femur dexter dengan fiksasi pin intramedular. Selanjutnya  2 minggu pasca operasi tikus percobaan dibagi secara acak dalam 3 kelompok (kelompok I, II, dan III), masing-masing 6 ekor tikus dengan pembagian sebagai berikut: tikus kelompok I (kontrol) diberi pakan standar (normal), tikus kelompok II diberi pakan standar + suplemen  CaCo3 150 mg/hari per oral, tikus kelompok III diberi pakan standar + ekstrak Cissus Qudrangularis 500 mg/hari. Terapi Cissus Quadrangularis diberikan selama 4 minggu. Pemeriksaan radiografi dilakukan dua kali yaitu pada minggu ke-3 dan minggu ke-6 pasca operasi. Hasil Penelitian gambaran radiografi tulang femur kanan pasca operasi reposisi patah tulang femur pada kelompok perlakuan III menunjukkan proses kesembuhan patah tulang yang terbaik dibanding kelompok perlakuan lainnya, dengan scoring tertinggi meskipun tidak berbeda nyata (p>0,05) dengan kelompok II. Scoring terendah diperoleh kelompok I yang berbeda nyata (p<0,05) dengan kelompok II dan III   Abstract    This study aims to compare the effect of calcium carbonate supplementation with Cissus quadrangularis (CQ) in accelerating the healing process of fractures of the femur in rats based on radiological evaluation. This study used 18 male white rats (Rattus Norwegicus) age of 12 weeks. After 1 week of adaptation, all rats were treated reposition of femoral dexter fractures with intramedullary pin fixation. The rats model were evenly randomly divided into three groups at 2 weeks after surgery: group I treated with normal diet, group II with normal diet + CaCo3 supplement 150 mg/day, group III with normal diet + Cissus Qudrangularis  500 mg / day per oral.  Cissus Quadrangularis therapy given for 4 weeks. Radiographic examination is conducted twice at 3th and 6th week post-surgery. The results of radiological evaluation on femoral dexter  with intramedullary pin fixation in the treatment group III showed the fracture healing process is best compared to other treatment groups, with the highest scoring, although not significantly different (p> 0.05) in group II. The lowest scoring group I obtained a significantly different (p <0.05) with group II and III.

Keyword :

Cissus quadrangularis, CaCo3, patah tulang, radiografi,


References :

Bhandari M, Guyatt GH, Swiontkowski MF ,(2002) A lack of consensus in the assessment of fracture healing among orthopaedic surgeons.J Orthop Trauma; 16(8):562–566 - : -

Cortes BP, Lawndale CA, Hingorani L, Thawani V. ,(2005) Use of the plant Cissus quadrangularis or its extracts for osteo-health including prevention or mitigation of degenerative disease, fracture healing and anabolic increase in osteo tissues. United States Patent Application Publication.March.3 - : -

Deka DK, Lahon LC, Saikia J, Mukit A,(1994) Effect of Cissus quadrangularis in Accelerating Healing Process of Experimentally Fractured Radius-Ulna of Dog: A Preliminary Study. Indian Journal of Pharmacology. 26: 44-45 - : -

Ghozali I,(2006) Statitik Non-Parametrik Teori dan Aplikasinya dengan Program SPSS. Badan Penerbit Universitas Diponegoro. Semarang. - : -

Iwamoto J, Seki A, Sato Y, Matsumoto, Tadeda T, Yeh JK,(2010) Vitamin K2 Promotes Bone Healing in a Rat Femoral Osteotomy Model wit



Archive Article

Cover Media Content

Volume : 30 / No. : 1 / Pub. : 2014-01
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  2. Peningkatan Kualitas Semen Beku Kambing Pe Melalui Suplementasi Antioksidan α–tocoferol Dalam Pengencer Semen Untuk Inseminasi Buatan
  3. Radiological Evaluation Of Femoral Fractures Healing In Male Rat With Cissus Quadrangularis Extract
  4. Characteristic Of Carcas, Meat Tenderness And Marbling Of Beef Cattle At Manokwari
  5. Concentration Determination Of Growth Factor Insuline Like Growth Factor-1 (igf-1) Produced By Liver And Cumulus Cells Monolayer Culture
  6. Morphometry Of The Kidney And Abdominal Aorta Of Indonesian Domestic Cat Through Two Dimensional Ultrasonography Diagnostic Approach
  7. Grant Of Ethanol Extract Of Seeds Papaya (carica Papaya) In Female Rats (rattus Novergicus) As An Alternative Antifertility Material To Fertilization Number
  8. The Potency Of Potassium Chloride And Sodium Bicarbonate Suplementation As Thermotolerance Agent On Liver Of Chronic Heat-stressed Broiler

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