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Media Kedokteran Hewan

ISSN 2015-8930

Vol. 21 / No. 3 / Published : 2005-09

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Original Article :

The pharmacogenetic study of diminazene aceturate in infected trypanposome and healthies goats by analysis of t1/2

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      Abstract :

      The aims of this research were finding the polymorphism phenomenon of diminazene aceturate in etawa breed goats by modus analysis of T1/2 . The five infected trypanosome goats and five healthies goats ware injected 5 mg/kg body weight diminazene aceturate by intramuscular administrated. The whole blood samples was obtained from sampling each 10, 30, 50, 70, 90, 120, 240, 720, 1440, 2880, 5760, 10080 minutes. The analytes in goats plasma was analysis by high performance liquid chromatography. The result showed that the pharmacogenetics profile of diminazene aceturate was bimode. Two mode being at 83.43 hours-1 and 122.5 hours –1.

      Keyword :

      diminazene aceturate, bimodus, elimination half life,


      References :



           


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