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Media Kedokteran Hewan

ISSN 2015-8930

Vol. 24 / No. 1 / Published : 2008-01

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Original Article :

The inhibition of vitamin e (α- tocopherol ) antioxidant to superoxide radical reactive oxygen species (o2.-) production on the white rat (rattus norvegicus)stressed by an electric shock

Author :

  1. Lilik Maslachah*1
  2. Rahmi Sugihartuti*2
  3. Rahma Kurniasanti*3
  1. Therapeutika Veteriner , Fakultas Kedokteran Hewan, Kampus C Universitas Airlangga,
    Jl. Mulyorejo Surabaya-60115. Tlp. 031-5992785
  2. Therapeutika Veteriner , Fakultas Kedokteran Hewan, Kampus C Universitas Airlangga,
    Jl. Mulyorejo Surabaya-60115. Tlp. 031-5992785
  3. Pharmacology Veteriner Departemen Ilmu Kedokteran Dasar Veteriner , Fakultas Kedokteran Hewan, Kampus C Universitas Airlangga,
    Jl. Mulyorejo Surabaya-60115. Tlp. 031-5992785

Abstract :

The research was done to prove the inhibition of antioxidant vitamin E (α- tocopherol) 400 IU to superoxide radical reactive oxygen spesies (O2) production on the white rats (Rattus norvegicus ) serum stressed by an electric shocks. There were twenty one Wistar males divided into three groups ( P0, P1 and P2). P0 (control) was given 3 ml drug solution, P1 was given a stressor and 3 ml drug solution. P2 was given a stressor and vitamin E emulsion. The treatment were done every day for 14 days. The serum blood of each treatment was carried out at day fourteen and were examined for radical superoxide (O2) level. It could be concluded that 3ml vitamin E (α- tocopherol) 400 IU could decrease the Reactive Oxygen Species (ROS) radical superoxide on the rats stressed by an electric shock.

Keyword :

α- tocopherol, stressor, radical superoxide ,


References :

  1. S Acker, (2003). Molecular Pharmacology of Vitamin E : Structural Aspects of Antioxidant Activity.. - : Ncbi.nlm.com
  2. I Alwi, (1996). Peran triad lipid pada penyakit jantung koroner. - : Medika. Desember No.12 Thn.XXII
  3. E Asnar, (2001). Peran Perubahan Limfosit Penghasil Sitokin dan Peptida Motilitas Usus Terhadap Modulasi Respon Imun Mukosal Tikus Yang Stres Akibat Stresor Renjatan Listrik. Surabaya : Universitas Airlangga
  4. R Kusriningrum, (1989). Dasar Perancangan Percobaan dan Rancangan Acak Lengkap. Surabaya : Fakultas Kedokteran Hewan. Universitas Airlangga
  5. L Maslachah, (2000). Pengaruh antioksidan probucol terhadap kadar malondialdehide (mda) dalam darah dan jumlah circulating endothel pada tikus yang menerima stressor. Surabaya : Fakultas Kedokteran Hewan. Universitas Airlangga
  6. A Wijaya, (1996). Radikal bebas dan parameter status antioksidan. - : Forum Diagnostikum Prodia. Diag¬nos¬tics Educational Cervices


   


Archive Article

Cover Media Content

Volume : 24 / No. : 1 / Pub. : 2008-01
  1. Antigenecity, sensitivity and spesificity of 27-28 kda protein of fasciola spp excretory-secretory (es) material for distomatosis diagnosis in cattle sera by using indirect-elisa technique
  2. Detection of toxoplasma gondii on the local chicken eggs sold as the mixture of traditional medicine in surabaya using biological test
  3. Identification of avian reovirus in chickens with tenosynovitis using indirect sandwich-elisa and protein characterization by western blot
  4. The inhibition of vitamin e (α- tocopherol ) antioxidant to superoxide radical reactive oxygen species (o2.-) production on the white rat (rattus norvegicus)stressed by an electric shock
  5. Intravenous phosphate infusion results in hyperphosphatemia and hypocalcemia without changing in plasma parathyroid hormone and calcitriol concentrations in goats
  6. Ultrasonography Diagnostic For Detection Of The Uterus Disorders In Cats (felis Catus)
  7. Potency of mengkudu (morinda citrifolia) juice extraction on carcass quality, vitamin c level and malonedialdehide (mda) level in broiler’s blood
  8. Comparison of fertility of etawa crossbred goats in low versus ideal body condition score after estrus synchronization and artificial insemination
  9. Digestibility and consumption of dry matter and organic matter in haylage complete feed ongole crossbreed steers
  10. The increase of desidual macrophages activity in infected toxoplasma gondii pregnant mice
  11. Restricted feeding delayed sexual maturation, decrease biometry of reproductive organ and fat deposition of quail hens (coturnix coturnix japonica)
  12. Detection of toxoplasma gondii on the local chicken eggs sold as the mixture of traditional medicine in surabaya using biological test
  13. The increase of desidual macrophages activity in infected toxoplasma gondii pregnant mice