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Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 21 / No. 3 / Published : 2013-09

TOC : 1, and page :89 - 93

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Original Article :

Comparison of the number and size of the dominant follicles with estradiol levels on pcos with naltrexone and clomiphene citrate therapy

Author :

  1. Muhammad Nur*1
  2. Budi Santoso*2
  3. Samsulhadi*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

The success rate of clomiphene citrate, the first-line therapy in PCOS, is only 30-40% pregnancy. Naltrexone combination withclomiphene citrate produced improved endocrine and metabolic changes in PCOS. This study compared the number, size dominantfollicle and estradiol levels in PCOS after naltrexone and clomiphene citrate therapy. This was an experimental study with pre andpost test control group design, performed in PCOS patients by Rotterdam criteria. The population was divided into treatment groupreceiving naltrexone for 5 days from menstrual cycle day 3 to 7 in a dose of 50, 100, and 150 mg/day for first, second, and thirdcycle, and control group receiving clomiphene citrate for 5 days in a dose of 50, 100, and 150 mg/day for third cycle. Serumestradiol and TVS were measuredin both to find dominant follicles on day 3 and 12 of menstrual cycle. Number, dominant folliclesize with estradiol level were compared.Regarding dominant follicle,in naltrexone group, from 18 cycles, 3 subjects had it in firstcycle. In clomifen citrate group, from 20 cycles, it was found in 2 in first cycle and 2 in third cycle. Mann-Whitney test showeddominant follicle size had no significant differences (p = 0.400) between naltrexon (19.70 ± 2.261) and clomiphene citrate (18.45 ±2.017)group. Estradiol levels in subjects with dominant follicle showed no significant differences (p = 0.057) between naltrexon(260.7 ± 11.51) and clomiphene citrate group (272.4 ± 2.92). In conclusion, number and size of dominant follicle and estradiol levelsdid not differ significantly in both groups.(MOG 2013;21:89-93)

Keyword :

PCOS, naltrexone, clomiphene citrate, estradiol, follicle,


References :

  1. Goodarzi MO, Dumesic DA, Chazenbalk G and Azziz R, (2011). Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. - : Nat Rev Endocrinol
  2. Samsulhadi, (1999). Ovarium polikistik dan permasalahannya. - : Majalah Obstetri dan Ginekologi


   


Archive Article

Cover Media Content

Volume : 21 / No. : 3 / Pub. : 2013-09
  1. Comparison of the number and size of the dominant follicles with estradiol levels on pcos with naltrexone and clomiphene citrate therapy
  2. Comparison of homa-ir, uterine and spiral artery resistance and endometrium in pcos patient with clomiphen citrate and naltrexone treatment
  3. Comparison of current events ovulation 12 hours and 36 hours after hcg administration in intra uterine insemination
  4. Post void residual reduction by administering misoprostol during post caesarean section
  5. Perbandingan kadar brain derived neurotrophic factor (bdnf) serum darah tali pusat bayi baru lahir antara ibu hamil yang mendapat dha dengan kombinasi dha dan 11-14 karya mozart selama hamil
  6. Efektivitas terapi rat bone marrow stem cell pada tikus model sindroma ovarium poli kistik terhadap folikulogenesis dan ekspresi transforming growth factor-b
  7. Igf-1 levels related to incidence of macrosomia