Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 21 / No. 3 / Published : 2013-09

Order : 7, and page :121 - 124

Related with : Scholar   Yahoo!   Bing

Original Article :

Igf-1 levels related to incidence of macrosomia

Author :

  1. Freddy Welly Wagey*1
  2. Kaeng Joice*2
  3. Indriani*3
  1. -
  2. -
  3. -

Abstract :

Macrosomia is used to describe a large baby with birthweight 4000 grams or more. Macrosomia incidence has increased over recentdecades and is associated with increased maternal and fetal morbidity and mortality. IGF-1 is an important regulator of fetalgrowth. The objective of this study was to find the relationship between IGF-1 levels with incidence of macrosomia. Study design wascorrelative with cross-sectional studies. Population were women who delivered macrosomias and normal babies in Prof. Dr. R.D.Kandou Hospital Manado and RW Mongisidi Hospital Manado. Sample of study is population who meet inclusion and exclusioncriterias. This study involved 65 women who meet inclusion and exclusion criteria. A total of 48 women gave birth to normal weightbabies and 17 women gave birth to macrosomia. Sample characteristics based on general age: 20-34 years (82% macrosomia, 64%normal birth weight), highest parity was multiparous (71%), most frequent maternal education level on macrosomia was elementaryschool (28%). The most frequent mode of delivery in macrosomia was cesarean section (59%). Most frequent BMI before pregnancywas obesity (53%) in macrosomia and 63% of normal BMI in normal weight. After logistic regression analysis, there was asignificant correlation between IGF-1 with the incidence of macrosomia (p = 0048 <0.05), with cut off point 195 ng/mL (sensitivity88.2%, specificity 97.9%). In conclusion, IGF-1 level was significantly associated with incidence of macrosomia. Analysis result ofthe relationship between IGF-1 levels with the incidence of macrosomia obtained cut-off point levels of IGF-1 at 195 ng/mL with asensitivity of 88.2% and specificity 97.9%.(MOG 2013;21:121-124)

Keyword :

IGF-1, macrosomia, -, -, -,

References :

  1. Cunningham G, (2005). Macrosomia. Boston : Williams Obstetrics
  2. Benson RC, (2007). Disproportionale Fetal Growth. Toronto : Current Obsgyn, Diagnosis and Treatment

Archive Article

Cover Media Content

Volume : 21 / No. : 3 / Pub. : 2013-09
  1. Comparison of the number and size of the dominant follicles with estradiol levels on pcos with naltrexone and clomiphene citrate therapy
  2. Comparison of homa-ir, uterine and spiral artery resistance and endometrium in pcos patient with clomiphen citrate and naltrexone treatment
  3. Comparison of current events ovulation 12 hours and 36 hours after hcg administration in intra uterine insemination
  4. Post void residual reduction by administering misoprostol during post caesarean section
  5. Perbandingan kadar brain derived neurotrophic factor (bdnf) serum darah tali pusat bayi baru lahir antara ibu hamil yang mendapat dha dengan kombinasi dha dan 11-14 karya mozart selama hamil
  6. Efektivitas terapi rat bone marrow stem cell pada tikus model sindroma ovarium poli kistik terhadap folikulogenesis dan ekspresi transforming growth factor-b
  7. Igf-1 levels related to incidence of macrosomia