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ISSN 2302-6464

Vol. 3 / No. 1 / Published : 2014-04

TOC : 6, and page :175 - 180

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Original Article :

Potential of vitamin e (α-tocopherol) of malondialdehyde (mda) levels testis mice (mus muscular) induced 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (tcdd)

Author :

  1. Rosida Achlis*1
  1. Mahasiswa Fakultas Kedokteran Hewan

Abstract :

This research was aimed to investigate the effect of vitamin E on testicular Malondialdehyde (MDA) level in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Five experimental groups of a combination of TCDD and vitamin E were designed as follows: 0 ng/kg/d and 0 mg/kg/d (control group), 100 ng/kg/d and 0 mg/kg/d (Group I), 100 ng/kg/d and 11 mg/kg/d (Group II), 100 ng/kg/d and 20 mg/kg/d (Group III), and 100 ng/kg/d and 37 mg/kg/d (Group IV) respectively. Vitamin E and TCDD were given by oral gavage for 9 days. The results demonstrated that TCDD increased level of Malondialdehyde (MDA). Vitamin E can protect the negative effect caused by exposured to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Best dose of vitamin E is 37 mg/kg/d decreased level of testicular Malondialdehyde (MDA).

Keyword :

mice, Vitamin E, Malondialdehyde, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin,

References :

  1. Adikwu, E. and B. Nelson. , (2012). Hepatoprotective Effect of Vitamin A. . USA : American J. of Pharm. and Toxicol. 7(4): 154-163.
  2. Agarwal, A., A. Prabakaran, and T.M. Said. , (2005). Oxidative Stress and Anti-oxidants in Male Infertility a Difficult Balance, . Iran : Iranian Journal of Repro-ductive Medicine, 3(1): 1-8.
  3. Aly, Hamdy., and R.M. Khafagy. , (2011). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Induced Cytotoxicity Accom-panied by Oxidative Stress in Rat Sertoli Cells: Possible Role of Mitochondrial Fractions of Sertoli Cells. . USA : Toxicology and Applied Pharmacology 252:273–280.
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Archive Article

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Volume : 3 / No. : 1 / Pub. : 2014-04
  1. Morning and evening serum testosterone level of limousine crossbreed bulls
  2. Test potential polyclonal antibodies local (abpo local pmsg) and patents (abpo patent pmsg) pmsg (pregnant mare serum gonadotropin) from male rabbit (oryctolagus cuniculus) to pregnancy mice (mus musculus)
  3. Dna fragmentation as apoptotic indicator and it relation with sperm viability and motility of domba ekor gemuk frozen semen in different thawing duration
  4. Determination encoding genes heat stable toxin (st) and protein of pathogens escherichia coli pili k99 was isolated from dairy cow feces using polymerase chain reaction (pcr)
  5. Biopotensi pmsg (pregnant mare serum gonadotrophin) local horse to speed time arising estrus, number of follicles, corpus luteum, progesterone levels and pregnancy rate in madura cattle
  6. Potential of vitamin e (α-tocopherol) of malondialdehyde (mda) levels testis mice (mus muscular) induced 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (tcdd)
  7. Effect of “sarang semut” (myrmecodia pendans) on the number of spermatogenic cells in seminiferous tubules of mice (mus musculus) with excessive physical treatment
  8. The effect of estrous syncronization by pgf2α and superovulation by pmsg and hcg and artificial insemination on heat response, pregnancy rates, litter size and sex ratio of the crossbread etawa goat
  9. Examination of fresh semen quality of merino sheep for frozen semen production in teaching farm of veterinary medicine faculty of airlangga university
  10. Identification of sperm morphometry in merino sheep and fat-tailed sheep
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  12. Profile of progesterone and insulin-like growth factor-i (igf-i) in pregnant crossbred mare serum
  13. Effect of equilibration time extender to post thawing motility and viability of merino sheep’s sperms in egg yolk skim diluents
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