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Detail Article

Planta Husada

ISSN 2338-7130

Vol. 2 / No. 1 / Published : 2014-04

TOC : 3, and page :12 - 15

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Original Article :

Antiangiogenesis from pericarp of mangosteen on t47d breast cancer

Author :

  1. Lusiana Arifianti*1
  2. Sukardiman*2
  3. Siti Rofida*3
  4. Noor Cholies Zaini*4
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi Univ Muhammadiyah Malang
  4. Dosen Fakultas Farmasi

Abstract :

Mangosteen (Garcinia mangostana Linn.) are generally cultivated in tropical rain forest area in Southeast Asia, especially in Indonesia. Mangosteen are well known to be rich in xanthone compounds and have anticancer activity. This study was aimed to know the mechanisms of action as an anticancer agent, such as an angiogenesis inhibitor on the T47D breast cancer cell line by suppressing angiogenic factor (VEGF) in vitro from the ethanol extract and actives fractions of mangosteen pericarp. The materials test of this study were the ethanol extract of mangosteen pericarp and fractions 2, 2.2 and 2.2.4 that generated from separations on previous study. In this study, we determine the antiangiogenic potency on T47D breast cancer through determination of expression percentage of VEGF as angiogenic factor by imunocytochemistry assay method. The result showed that the ethanol extract and the active fractions possesed antiangiogenic potency and the fraction of 2.2.4 was the most potent with the lowest percentage of VEGF expression (24,67% ± 4,51). It can be concluded that chemical components that contained in the extract and the fractions of mangosteen pericarp gived angiogenesis inhibition on T47D breast cancer cell. Based on this result, the ethanol extract and the active fractions of mangosteen pericarp were potential to be delevoped as antiangiogenic agent in breast cancer metastase.  

Keyword :

Garcinia mangostana, angiogenesis, VEGF, T47D, Breast Cancer,


References :

  1. Lim, T.K, (2012). Garcinia mangostana. In:Edible Medicine and Non Medicine, Vol. 2 Fruts. Dondhrect Holdberg London New York : Springer Science and Business Media BV
  2. Meiyanto, E., Melannisa, R., Da’I, M, (2006). PGV-1 decreases angiogenic factor (VEGF and COX-2) expression on T47D cell induced by estrogen. - : Majalah Farmasi Indonesia
  3. Tiwari, M, (2012). Apoptosis, Angiogenesis and Cancer Therapies. - : Jour. of canc ther and res
  4. Chin, Y.W., and Kinghorn, A.D, (2008). Structural Characterization, Biological Effect, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.. - : Organic Chemistry
  5. Yang, S., Zhao, Z., Wu, R., Lu, H., Zhang, X., Wu., X, and Guan G, (2011). Expression and biological relationship VEGF-A and MMP in gastric carcinoma. - : The Jour. of Int. Med. Res


   


Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2014-04
  1. Eluent effect on sinensetin in orthosiphon stamineus benth. leaves extract
  2. Ethyl acetate fraction of andrographis paniculata nees increases cytotoxic effect of vincristine on human cancer cell lines
  3. Antiangiogenesis from pericarp of mangosteen on t47d breast cancer
  4. Ethyl acetate fraction of johar leaves (cassia siamea lamk) on plasmodium falciparum strain g2300 (chloroquin resistence) in vitro as an antimalaria activity
  5. Pinostrobin isolated from kaempferia pandurata roxb induced apoptosis in t47d human beast cancer cell line