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Detail Article

Planta Husada

ISSN 2338-7130

Vol. 2 / No. 2 / Published : 2014-10

TOC : 5, and page :44 - 46

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Original Article :

Anticancer effect of pinostrobin from (kaempferia pandurata roxb) in benzo(a)pyrene – induced fibrosaroma in mice

Author :

  1. Sukardiman *1
  1. Dosen Fakultas Farmasi

Abstract :

Pinostrobin. a flavonoid purified from  the Indonesian herb (Kaempferia pandurata Roxb) . was tested for antitumor  properties in several model system. In vitro. pinostrobin inhibited proliferation of primary  human breast cells.  human breast cells line MC7. and mieloma cells .  The aim of this study  was to investigated the inhibitory effect of pinostrobin isolated from Kaempferia pandurata Roxb on the growth of  solid  tumor of  benzop(a)pyrene – induced fibrosarcoma in mice in vivo. The inhibition of solid tumor was measured by weight of tumor and histological observation. These result indicated that pinostrobin showed inhibitory effects on the growth of  solid  tumor of  benzop(a)pyrene – induced fibrosarcoma in mice.  

Keyword :

Anticancer, Kaempferia pandurata Roxb , pinostrobin, fibrosarcoma,


References :

  1. Sukardiman, Darwanto A., Darmadi O.M., , (2000). Cytotoxic mechanism of flavonoid from Temu Kunci (Kaempferia pandurata) in cell culture of human mammary carcinoma . Vol 23, pp 185-190. : Clinical Hemorheologyand Microcirculation
  2. Sukardiman, (2003). Anticancer Activity of Pinostrobin from Temu Kunci from Kaempferia pandurata againts Cell Culture of Mieloma. vol : Media Kedokteran


   


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Volume : 2 / No. : 2 / Pub. : 2014-10
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  5. Anticancer effect of pinostrobin from (kaempferia pandurata roxb) in benzo(a)pyrene – induced fibrosaroma in mice