UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 1 / Published : 2012-07

Order : 4, and page :21 - 31

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Original Article :

Pengaruh penambahan manitol terhadap pelepasan ranitidin hcl dari tablet floating dengan hpmc k100m sebagai matriks

Author :

  1. Hafid Fadillah Akbar*1
  2. Sugiyartono*2
  3. Dwi Setiawan*3
  1. Departemen Farmasetika, Fakultas Farmasi, Universitas Airlangga Surabaya
  2. Corresponding Author, Departemen Farmasetika, Fakultas Farmasi, Universitas Airlangga Surabaya
  3. Departemen Farmasetika, Fakultas Farmasi, Universitas Airlangga Surabaya

Abstract :

Ranitidine is one of the drug of choice for the treatment of active duodenal ulcers gastric ulcers and Zollinger Ellison syndrome. The drug is absorbed only in the initial part of the small intestine. Colonic metabolism of ranitidine is also partly responsible for the poor bioavailability of ranitidine from the colon. All these factors highlight the need to develop a gastro retentive floating system as a sustained release dosage form. The tablets are prepared by wet granulated technique, using hydrophilic  matrix polymers HPMC K100M, combined with mannitol , as a substance that increase the drug release, because HPMCK100M have a high viscosity and high retardant ability. The tablets were   evaluated for in vitro release for 8 hours in 0,1 N HCl at 370  C. The result shows that mannitol increase ranitidine HCl release.

Keyword :

Ranitidine HCL, Floating Tablets, HPMC,


References :

Ansel, H. C., Popovich, N. G. dan Allen, L.V. Jr. ,(1995) Pharmaceutical Dosage Forms and Drug Delivery System Philadelphia : Philadelphia : Lea & Febiger

Arora, S., Ali, J., Ahuja, A., Khar, R.K. dan Baboota, S. ,(2005) Floating Drug Deliery System: A Review. - : AAPS PharmaSciTech

Aulton, Michael E. ,(2002) Pharmaceutics The Science of Dosage Form Design London : Churchill Livingstone

Bandelin, F.J. ,(2002) Compressed Tablet by Wet Granulation New York : Marcell Dekker Inc

Banker and Anderson, Lieberman H.A. et al. ,(1986) Pharmaceutical Dosage Forms New York : Marcell Dekker Inc





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2012-07
  1. Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak Dalam Sistem Niosom Dengan Basis Gel Carbomer 940
  2. Physical Characterization And In Vitro Release Study On Theophylline-chitosan Microparticles (effect On Crosslinking Time And Method Of Preparation)
  3. Characterisation Of Solid Lipid Nanoparticles P-methoxycinnamic Acid (sln-pmca) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol
  4. Pengaruh Penambahan Manitol Terhadap Pelepasan Ranitidin Hcl Dari Tablet Floating Dengan Hpmc K100m Sebagai Matriks
  5. The Influence Of Niosome System (span 20/60-cholesterol) On The Preparation Characteristics And Released Of Diclofenac Sodium From Gel Carbopol Etd 2020

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