Detail Article

Jurnal Rekonstruksi & Estetik

ISSN 2301-7937

Vol. 2 / No. 2 / Published : 2013-12

Order : 3, and page :11 - 15

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Original Article :

Effects of topical pomegranate peel extract on healing of split thickness wound in rats

Author :

  1. Iswinarno Doso Saputro*1
  2. Vini Thresianty Irene Prima Tanggo*2
  3. Agus Santoso Budi*3
  1. Dosen
  2. Mahasiswa
  3. Dosen

Abstract :

Background : Split thickness skin grafting (STG) is a frequently used technique for covering soft tissue and skin defects. Donor sites created after harvesting a split-thickness skin graft present an additional wound to manage. The management of the donor site after removing the skin graft is an important patient comfort issue. A suitable wound dressing helps to achieve wound healing and to satisfy patients barring any complications, such as infection or pain. Although numerous dressings have been studied, there is not one perfect dressing for use on the donor site that is easy to use, provides patient comfort, prevents infection, is inexpensive, and promotes faster re-epithelization.   Objective : The aim of this study is to examine the effect of topical pomegranate peel extract application on split thickness wound healing.   Method : A prospective experimental study carried out on 14 male rats at about 3 months old. Two split thickness skin graft donor sites were made on the back in each animal, one control, and the other in which topical pomegranate peel extract was applied. Skin specimens were collected on the 3rd and 10th days from 7 different rats at each period. The sections were stained with hematoxyllin-eosin for examining the number of fibroblast and collagen thickness.   Results: Pomegranate peel extract increase the number of fibroblast and collagen thickness in inflammation phase but decrease the number of fibroblast and collagen thickness in proliferative phase meanwhile promotes rapid re-epithelization.  

Keyword :

Pomegranate peel extract, skin graft, wound healing,

References :

  1. Adiga S., Tomar P., Rajput R.R, (2010). Effect of Punica granatum Peel Aqueous Extract on Normal and Dexamethasone Suppressed Wound Healing in Wistar Rats. USA : International Journal of Pharmaceutical Sciences Review and Research

Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2013-12
  1. Medical breakthrough of anthropometric methods as basis for 3d digital modelling of indonesian female facial type
  2. The effect of giving single strain probiotics
  3. Effects of topical pomegranate peel extract on healing of split thickness wound in rats
  4. Effect of topical pomegranate peel extract on methicillin resistant staphylococcus aureus bacteria on second degree burn wound in rat strain wistar
  5. Role of topical extract aloe vera gel in deep burn wound healing in rat
  6. Comparison of the effectivity of giving topical low molecular weight hyaluronate with povidone iodine on healing the full thickness wounds colonized by pseudomonas aeruginosa in white rats
  7. Pengaruh pemberian topikal low molecular weight hyaluronate pada epitelialisasi luka superfisial tikus putih yang dirawat dengan membran amnion freeze-dried
  8. Effect of oral pomegranate (punica granatum) peel aqueous extract on macrophage, fibroblast and collagen thickness burn wound healing
  9. The role of topical vitamin c and its derivative in promoting skin wound healing in rats
  10. Effects of collagen wound dressing on wound healing in rat skin wound