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Jurnal Rekonstruksi & Estetik

ISSN 2301-7937

Vol. 2 / No. 2 / Published : 2013-12

TOC : 5, and page :26 - 30

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Original Article :

Role of topical extract aloe vera gel in deep burn wound healing in rat

Author :

  1. Taufiq Sakti Noer Hidayat*1
  2. M. Sjaifuddin Noer*2
  3. Sitti Rizaliyana*3
  1. Mahasiswa
  2. Dosen
  3. Dosen

Abstract :

Introduction: Burn injury is a common cause of morbidity and mortality. Outcomes of morbidity and disability for deep burns patients still not improved. Many modalities for wound bed preparation was not satisfied. Aloe vera gel have been used as an anti-inflammatory natural agent, for treatment many deseases. It has also been used in the traditional medicine of many cultures and said to be beneficial in the treatment of disorders such as burns. Objective: The aim of this study is to formulate a topical cream from extract aloe vera gel with wound deep burn healing effect and to performed its in rat. Methods: An experimental study. A total of 12 wistar rats in the age range of 3 month with deep burn wounds on their both backs will select for the study. The subjects used aloe vera gel topical formulation or moist conditions on each backs as the test and control, symmetrically. And then histopathological samplings will measure. Results: A topical cream from extract aloe vera gel play a part in increase the number of lumen vessels at inflammatory phase significantly (p<0,05). The number of macrophages, the number of fibroblast and collagen tickness at inflammatory phase and proliferation phase was increase notiwithstanding not significant. A topical cream from extract aloe vera gel also has antiinflammatory effect. Discussion: A topical cream from extract aloe vera gel play role in wound deep burn healing effect by increase of the number of lumen vessels, the number of macrophages, the number of fibroblast and collagen tickness at inflammatory phase and proliferation phase and also has antiinflammatory effect by push down of inflammatory reaction.

Keyword :

deep burn injury, extract aloe vera gel, wound healing, rat,


References :

  1. Cindy, J.M., Loomans, Eelco, J.P., de Koning, Frank, J.T.S., Maarten, B.R., Caroline, V., Hetty, C.B, (2004). Endothelial Progenitor Cell Dysfunction A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes. USA : Diabetes
  2. Falanga, V, (2004). The chronic wound: impaired healing and solutions in the context of wound bed preparation. USA : Blood Cells, Molecules, and Diseases


   


Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2013-12
  1. Medical breakthrough of anthropometric methods as basis for 3d digital modelling of indonesian female facial type
  2. The effect of giving single strain probiotics
  3. Effects of topical pomegranate peel extract on healing of split thickness wound in rats
  4. Effect of topical pomegranate peel extract on methicillin resistant staphylococcus aureus bacteria on second degree burn wound in rat strain wistar
  5. Role of topical extract aloe vera gel in deep burn wound healing in rat
  6. Comparison of the effectivity of giving topical low molecular weight hyaluronate with povidone iodine on healing the full thickness wounds colonized by pseudomonas aeruginosa in white rats
  7. Pengaruh pemberian topikal low molecular weight hyaluronate pada epitelialisasi luka superfisial tikus putih yang dirawat dengan membran amnion freeze-dried
  8. Effect of oral pomegranate (punica granatum) peel aqueous extract on macrophage, fibroblast and collagen thickness burn wound healing
  9. The role of topical vitamin c and its derivative in promoting skin wound healing in rats
  10. Effects of collagen wound dressing on wound healing in rat skin wound