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Jurnal Rekonstruksi & Estetik

ISSN 2301-7937

Vol. 2 / No. 1 / Published : 2013-01

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Original Article :

The effect of giving single strain probiotics to the degree of secretory immunoglobulin a on burn injury patients

Author :

  1. Nur Febriany Nasser*1
  2. Sitti Rizaliyana*2
  3. M. Sjaifuddin Noer*3
  1. mahasiswa
  2. dosen
  3. dosen

Abstract :

Introduction: Sepsis as a result of bacterial translocation from the gastrointestinal tract (GIT) is a known associate of morbidity and mortality in patients with severe burns. This translocation is influenced by the GIT flora. A less investigated mechanism that seems to contribute to sepsis in burns is bacterial translocation the passage of microorganisms and/or their products from the gastrointestinal tract (GIT) lumen. Retrospective study of burn injuried patients admitted in the burn care unit  Dr.Soetomo Hospital Surabaya, 14.1% patients were died. Within periode June 2009-June 2011 about 60% of mortality rate from burn patients (10,38%) due to sepsis. In Burn injury, there is an increase of intestinal permeability reperfusion resulted in an increased  risk of bacterial translocation and endotoxemia, histological lesions in mucosa and decreased levels of IgA and mucin. Oral consumptions of Bifidobacteria supplement can reduce the ratio of the balance of aerob bacteria, endotoxemia and mucosal lesions and reduce the symptoms of digestive disorders such as diarrhea in burn patients. Several treatment options were investigated to decrease bacterial translocation, among them a per os supplement of lactobacillus bacteria. Objective: Our study aimed to assess the effect of the probiotic single strain Lactobacillus and Bifidobacteria supplementation to increased the secretory IgA in intestines in burn patients. Method: An experimental study, double blind clinical trial. Clinical trial was carried out in minimal 16 burn patients. They were divided into 2 groups, 1 group ingested daily Lactobacillus supplement probiotic and the other took Bifidobacteria supplement probiotic, both for 14 days. Treatment was started on day 4 post burn injury. The degree of secretory IgA was evaluated on day 4 (before treatment) and day 14 from faecal specimen. Data will be compared with results from previous research.

Keyword :

probiotics, sIgA, Lactobacillus, Bifidobacteria, Sepsis,


References :

  1. Koren L. et al, (2007). The Effect of Lactobacillus Bacteria Supplement on Sepsis and Its Complications in Patients with acute Burns. New York : J Burns
  2. Eaves-Pyles, T, (1998). Rapid and Prolonged impairment of Gut Barrier Function After Thermal Injury in Mice. New York : Shock
  3. Quigley E.A.M., Quera R, (2006). Small Intestinal Bacterial Overgrowth : Roles of Antibiotics, Prebiotics and Probiotics. New York : Gastroenterology


   


Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-01
  1. The effect of intravenous vitamin c on nitric oxide serum level in severe burn injury
  2. Effectivity of topical chitosan on exudative chronic wound management
  3. Bactericidal effect of topical vitis vinifera on methicillin-resistant staphylococcus aureus (mrsa) on rattus norvegicus skin wound
  4. The effect of giving single strain probiotics to the degree of secretory immunoglobulin a on burn injury patients
  5. Pengaruh pemberian topikal low molecular weight hyaluronate pada epitelialisasi luka superfisial tikus putih yang dirawat dengan membran amnion freeze-dried
  6. The effect of 3000 mg vitamin c infusion on histamine level in severely burned patients
  7. The effect of amnion freeze – drying to prevent adhesion in rabbit tendon achilles healing
  8. Five years retrospective study of burns in dr. soetomo general hospital surabaya
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  10. The nasal profile of young indonesian women aged 19-21 years old judged to be atractive according to third year medical students of airlangga university
  11. Eye profile of indonesian young women aged 19-21 years judged to be attractive by third year medical students of airlangga university