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Detail Article

Jurnal Rekonstruksi & Estetik

ISSN 2301-7937

Vol. 2 / No. 2 / Published : 2013-12

TOC : 10, and page :51 - 55

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Original Article :

The role of topical vitamin c and its derivative in promoting skin wound healing in rats

Author :

  1. Priscilla*1
  2. David S Perdanakusuma*2
  1. Mahasiswa
  2. Dosen

Abstract :

Purpose   To verify the role of topical L-ascorbic acid and magnesium ascorbyl phosphate in promoting rats’ skin wound healing through the number of macrophages, neovessels and collagen thickness.       Method   27 male Rattus novergicus at about 3 months old were used. Three 15 mm longitudinal incisions were made at each rat’s back at different locations and sutured afterwards. The central wounds (CG) were cleaned with normal saline and savlon daily. The left wounds (TG 1) were cleaned daily and treated with 20% L-ascorbic acid serum. The right wounds (TG 2) were cleaned daily and treated with 15% magnesium ascorbyl phosphate serum. Skin specimens were collected on the 3rd, 7th and 21st days from 9 different rats at each period. The sections were stained with hematoxyllin-eosin for examining the number of macrophages, neovessels and collagen thickness.       Result   Both L-ascorbic acid and magnesium ascorbyl phosphate acted on every stage of healing process. Magnesium ascorbyl phosphate reduced the number of macrophages more than L- ascorbic acid did. It also induced collagen synthesis sooner and produced more organized collagen fibers compared to control and L-ascorbic acid groups. On the other hand, L-ascorbic acid could induce neovascularization better and produced thicker collagen fibers compared to control and magnesium ascorbyl phosphate.  

Keyword :

L-ascorbic acid, magnesium ascorbyl phosphate, macrophage, neovessel, collagen,


References :

  1. Falanga, V. 2004, (2010). ABC of Burns Intensive Care Management and Control Of Infection. USA : Lipincott Williams and Wilkins


   


Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2013-12
  1. Medical breakthrough of anthropometric methods as basis for 3d digital modelling of indonesian female facial type
  2. The effect of giving single strain probiotics
  3. Effects of topical pomegranate peel extract on healing of split thickness wound in rats
  4. Effect of topical pomegranate peel extract on methicillin resistant staphylococcus aureus bacteria on second degree burn wound in rat strain wistar
  5. Role of topical extract aloe vera gel in deep burn wound healing in rat
  6. Comparison of the effectivity of giving topical low molecular weight hyaluronate with povidone iodine on healing the full thickness wounds colonized by pseudomonas aeruginosa in white rats
  7. Pengaruh pemberian topikal low molecular weight hyaluronate pada epitelialisasi luka superfisial tikus putih yang dirawat dengan membran amnion freeze-dried
  8. Effect of oral pomegranate (punica granatum) peel aqueous extract on macrophage, fibroblast and collagen thickness burn wound healing
  9. The role of topical vitamin c and its derivative in promoting skin wound healing in rats
  10. Effects of collagen wound dressing on wound healing in rat skin wound