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Veterinaria Medika

ISSN 1979-1305

Vol. 5 / No. 1 / Published : 2012-02

TOC : 15, and page :73 - 76

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Original Article :

A comparison of the effect melatonin and forbetes on blood glucose level in rat (rattus norvegicus) experimentally diabetic mellitus type 1

Author :

  1. Setiawan, Boedi*1
  2. Perdana, F.R*2
  3. Wurlina*3
  4. Mumpuni, Sri*4
  1. Fakultas Kedokteran Hewan Universitas Airlangga
  2. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga
  4. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

The aim of this study were obtained the influence of melatonin and effective dose toward  in rat (Rattus norvegicus) which induced by alloksan. Thirty healthy wistar male rat (Rattus norvegicus) with 100 – 150 gram average body weight and two - three month old were used in this study.This rat were adapted for seven days and divided into six group. First group (P0) as control of normal bloodglucose, P1 which induced by alloksan intraperitoneally as negative control of diabetes mellitus type I.Mellatonin was given intraperitoneally as treatment on group P2, P3, and P4 using range dose to observe the effective dose of mellatonin as therapy of diabetes mellitus type I. Last group (P5) was given forbetes which has known as drug of choice for diabetes mellitus type I, orally as positif control. This study used Complete Random Design and the result has been analyzed using ANOVA (Analyzed of Varience) continued with Duncan’s Multiple Range Test method and processed by using SPSS computer software programe. The result shows that melatonin influence to reduce blood glucose on rat induced by alloksan as suspect of diabetes mellitus type I and there is significant differences (p<0,05) among the groups. Treatment using mellatonin 5 mg/kg body weight (P2) as the most effective dose to decrease blood glucose in rat induced by alloksan.

Keyword :

Melatonin, Aloksan, Diabetes mellitus tipe I,

References :

  1. Axentsev, S., E. Basch, H. Boon, M. Corrado, C. Dacey, P. Hammerness, N. Linardakis, C. Tsourounis, , (2006). Melatonin. . : http://www. /patientmelatonin.html. [19 Februari 2008]
  2. Price, S. A. and L. M. Wilson, (2002). Patofiologi Konsep Klinis Proses-Proses Penyakit. Volume 1. Jakarta : Penerbit Buku Kedokteran EGC


Archive Article

Cover Media Content

Volume : 5 / No. : 1 / Pub. : 2012-02
  1. Feed convertion and feed consumption of feed formulation with different protein content
  2. The potential of complete feed fermentation use cellulolityc bacteria to increase daily gain of sheep
  3. The effectivity of psidium guajava linn leaf dipping to chicken egg yolk quality
  4. The role of location against gastrointestinal nematodosis on cattle at west madura
  5. The activity test of whole bacterium suspension of bacillus thuringiensis subspecies israelensis serotype h-14 at mosquito of culex fatigans pipiens and aedes aegypti
  6. The metabolite levels of broiler serum that suffer due to warming heat stress in the long term
  7. Supplement of acrosin to the post thawing sperm of half-breed of etawa goat (pe) towards increasing potency of spermatozoa
  8. Quality test of frozen semens of fat-tailed sheep in three different kinds of semen extenders
  9. The level of progesteron in blood sera cows using ria( radio immuno assay ) after progesteron transvaginal mpa (medroxy progesteron acetate)
  10. Model plastik t sponge mpa (medroxy progesteron acetate) soft release for oestrus synchronization in cows
  11. Eimeria necatrix pathogenicity attenuation through a serial passage of precocious lines towards small intestine histopathology in broiler
  12. The effect of ethanol extracted of curcuma aeruginosa roxb rizhoma toward degree”s of kidney damage chicken layer which it is infected by ascridia galli
  13. Fluctuation of interleukin-4 ( il-4) in serum and reproductive organ at toxoplasma gondii infected pregnant mouse
  14. Expression difference of Αvβ3 in the endometrium after the administration clomiphene citrate, combination of clomiphene citrate and metformin, or metformin
  15. A comparison of the effect melatonin and forbetes on blood glucose level in rat (rattus norvegicus) experimentally diabetic mellitus type 1