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Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 1 / Published : 2017-02

TOC : 16, and page :119 - 130

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Original Article :

Androgen dihydrotestosterone and its role in male reproductive system

Author :

  1. Muslim Akmal*1
  1. Laboratorium Histologi Fakultas Kedokteran Hewan Universitas Syiah Kuala

Abstract :

Androgensarehormone that plays an importan role in male reproductivesystem and produced significantly in form of testosterone by Leydig cells in testesand found in circulating throughout the body. The formation of androgens is esensialin a number of androgen action and have specific role for male sexual differentiationand support spermatogenesis in adult rat. Dihydrotestosterone (DHT) is a more potentandrogen and the active ligand in a number of androgen target tissues and required formale reproductivetract development. DHT is metabolized significantly by reduction3α-hydroxysteroid dehydrogenase in liver or androgen target tissues and excreted in urin.

Keyword :

androgen, dihydrotestosterone, spermatogenesis, male fertility,

References :

  1. Andersson, S., R.W. Bishop. and D.W. Russell, (1989). Expression cloning and regulation of steroid 5 alphareductase, an enzyme essential for male sexual differentiation. 264: 16249-55 : J Biol Chem
  2. Askew., E.B., R.T. Gampe., T.B. Stanley., J.L. Faggart. and E.M. Wilson. 2007, (2007). Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone. 282(35) pp. 25801- 25816 : The Journal of Biological Chemistry
  3. Auchus, R.J., (2010). Management of the adult with congenital adrenal hyperplasia. 614107 : Int J Pediatr Endocrinol
  4. Bain, J, (2001). Andropause: Testosterone replacement therapy for aging men. 47: 91- 97. : Can Fam Physician


Archive Article

Cover Media Content

Volume : 10 / No. : 1 / Pub. : 2017-02
  1. Isolation and identification vibrio sp as vibriosis cause of agent at grouper fish (epinephelus fuscoguttatus) in banyuwangi regency
  2. Identification of species and stage of mite causes scabies by crusting severity on the rabbits
  3. Potency of curcumin on histopathological changes in the kidney of pregnant mice (mus musculus) exposed to cadmium
  4. Effect of vitamin c and e towards histopathological changes of duodenum in mice induced with borax
  5. The effects of crude protein bovine seminal plasma addition in skim milk and egg yolk diluent to motility, viability, dna fragmentation, and necrosis of ram spermatozoa after equilibration
  6. The effect of red fruit oil (pandanus conoideus lam.) on histopathology of follicle development in infertile mice modelling
  7. Prevalence and infection level of gastrointestinal worm nematode on long tailed macaque (macaca fascicularis) at taman wisata wendit malang regency
  8. Prevalence of distomatosis on various type of slaughtered cattle at penggaron semarang abattoir
  9. Pattern of antibiotics resistance on escherichia coli that isolated from raw milk in surabaya
  10. Effect of mangosteen (garcinia mangostana linn.) pericarp extracts on the diameter of mice (mus musculus) pre antral and antral follicles
  11. Semen quality, hsp 70 expression and dna damage of post thawing limousine bull spermatozoa after cooled at 5 °c
  12. The effects of propolis on histological liver in male mice (mus musculus)
  13. Effect of rosella flower (hibiscus sabdariffa l.) extract on liver histhopathologic of male mice (mus musculus) exposed plumbum acetate
  14. Effect of electrical field on the death of staphylococcus aures in milk
  15. The effect of mimosa pudica root extract to histopathological representation of rattus norvegicus liver injected with naja sputatrix venom
  16. Androgen dihydrotestosterone and its role in male reproductive system