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Veterinaria Medika

ISSN 1979-1305

Vol. 4 / No. 3 / Published : 2011-11

TOC : 14, and page :229 - 238

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Original Article :

Aphrodisiac bioscreening models, profile of justicia gendarussa burm.f., pimpinella pruatjan molkenb and pangium edule reinw. extracts on isolated frog gastric smooth muscle

Author :

  1. Bambang Prajogo E.W*1
  2. Indera P.*2
  3. Muzaki*3
  1. Fakultas Farmasi Unair
  2. Fakultas Farmasi Unair
  3. Fakultas Sains dan Teknologi Unair

Abstract :

The purpose of this research was to find the relaxation effect on smooth muscle of Pangium edule, Pimpinella pruatjan and Justicia gendarussa extracted by using Harvard apparatus electric kymograph. In this research on smooth muscle three different groups of concentration of 10 ppm, 50 ppm and 100 ppm of each were used extract. For the positive controls group acetylcholine (1 ppm), adrenaline (1 ppm) and papaverine (1 ppm) were given. Extracts and drugs that had been prepared were tested on frog gastric smooth muscle isolated immediately from the body of a frog, then soaked with thyrode and bubled by oxygen. Then data were analyzed by comparing peak contraction before and after treatment. Results, in 70% ethanol extract of J. gendarussa (114.85 ppm) 79.1% relaxation was obtained. In methanol extract of P.pruatjan (101.98 ppm) 72.1% relaxation was obtained, in methanol extract P. edule (103.96 ppm) 10.3% relaxation was obtained respectively. From results obtained, was known that solvent the can cause best relaxation was methanol. Further research to determine the effect Pangium edule, Pimpinella pruatjan and Justicia gendarussa extracts on corpus cavernosum smooth muscle, to determine specifically the influence of the penis was expected.

Keyword :

Pangium edule, Pimpinella pruatjan, Justicia gendarussa, Gastric Smooth Muscle, Frog,


References :

  1. Kim YC, W Choi, R Sung, H Kim, RY You, SM Park, S Youn, MJ Kim, YJ Song, WX Xu, SJ Lee and HY Yun, (2009). Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents. . : Korean J Physiol Pharmacol Vol 13: 503-510
  2. Prajogo BEW, (2002). Aktivitas Antifertilitas Flavonoid Daun Gendarusa vulgaris Ness. Penelitian Eksperimental Pencegahan Penetrasi Spermatozoa Mencit dalam Proses Fertilisassi In Vitro. Surabaya : Disertasi. Program Pasca Sarjana Universitas Airlangga
  3. Dirjen Pengawasan Obat dan Makanan, (2005). Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta : Depar-temen Kesehatan RI, hal 7 – 11


   


Archive Article

Cover Media Content

Volume : 4 / No. : 3 / Pub. : 2011-11
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  2. Crossbreds entog and duck artificial insemination technology of diluted and doses for fertibily
  3. Pengaruh pemberian alkaloid daun jarong (achyranthes aspera linn) pada mencit yang terkena kanker mammae terhadap gambaran hitung jenis leukosit
  4. Motilitas, persentase hidup dan keutuhan membran spermatozoa domba ekor gemuk post thawing dalam tiga macam diluter
  5. The quality of ram sperm after washing with brackett and oliphant’s (bo) medium at skim milk and egg yolk diluent
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  10. The prevalence of helminthiasis gastrointestinal tract of sumatran tiger (panthera tigris sumatrae) and bengal tiger (panthera tigris tigris) in three different areas of conservation
  11. Supplement of acrosin to the post thawing sperm of half-breed of etawa goat (pe) towards capacitation and acrosome reaction of spermatozoa
  12. The effectiveness of glutaraldehyde and didecyl dimethyl ammonium chloride combination as a disinfectant to decrease total number of bacteria on layer chicken cages
  13. Anti hy preparation as raw material for frozen semen and frozen female embryos
  14. Aphrodisiac bioscreening models, profile of justicia gendarussa burm.f., pimpinella pruatjan molkenb and pangium edule reinw. extracts on isolated frog gastric smooth muscle
  15. Application of human menopose gonadotrophin (hmg) toward follicle growth in cows ovary hypofunction