UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 6 / No. 3 / Published : 2013-11

Order : 10, and page :209 - 214

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Original Article :

Combination effect of echinacea purpurea and andrographis paniculata as hepatoprotector in white rat exposed by heat stress-

Author :

  1. Oktanella, Yudit*1
  2. Meles, IDK*2
  3. Hernawati, Tatik*3
  4. Wurlina*4
  1. Mahasiswa Program Magister Ilmu Biologi Reproduksi
  2. Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga
  4. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

Antioxidants contain of Andrographis paniculata and Echinacea purpurea have been proven to be beneficial to health. The purpose of this study was to determine whether the combination of the two plant extracts contains capable act as hepatoprotector against on heat stressed-rat. Thirty female rat with 2-3 monthof ages used as animal model were divided into five groups; K- (negative control), P0, P. They were given by a suspension containing the combination between Andrographis paniculata and Echinacea purpurea in several doses during 28 days before made to suffer from heat stress for 8 days as long as 30 minutes/day. Treatments consist of negative control which was not given by both treatments, P (0 capsule/200 gramBW/day), P1 (0,0252 capsule/200 gramBW/day), P 21, P2, P3 (0,0504 capsule/200gramBW/day), P(0,0756 capsule/200 gram BW/day) as long as 28 days advanced by heat stress treatment. The results of this study indicated that the combination of Andrographis paniculata extract and Echinacea purpurea is able to function as hepatoprotector by maintaining levels of SGOT and SGPT within normal limits. The effective dose are shown in group P1 and P2, with average SGOT and SGPT levels as low as K obtained from the treatment, with average levels of SGOT of 46,83U/l - 49,83U/l and SGPT of 24,67U/l - 26,17U/l. 

Keyword :

Andrographis paniculata, Echinacea purpurea, Heat stress, SGOT, SGPT,


References :

Cheunsombat, W., R. Banjerdpongchai, V. Rattanapanone and D. Punwong.,(2005) Pro-oxidant Effect of Extract from Andrographis paniculata Nees on Gluthatione levels in Human Erythrocytes. China : Chiang Mai Medical Journal 44(1):13-19.

Kapil, A., I. B. Koul, S. K. Banerjee and B. D. Gupta.,(1993) Antihepatotoxic effect of major diterpenoid constituents of Andrographis paniculata United States : Biochem Pharmacol 46(1):182-185.





Archive Article

Cover Media Content

Volume : 6 / No. : 3 / Pub. : 2013-11
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  2. Effectiveness Of Crioprotectant During Sperm Freezing Process Using Rapid Freezing Method Toward The Concentration Of Post Thawing-frozen Cow Semen Dna
  3. The Effectiveness Of Garlic (allium Sativum L.) Extract In Chicken Broiler’s Titer Antibodies That Vaccinated With Live Nd
  4. Reactivity Ib (infectious Bronchitis) Virus Field Isolate Passaged On Embryonated Chicken 1 Eggs Against Antibody Post Vaccination
  5. Different Animals Species Hairs As Biological Tool For The Veterinary Forensic Assessement Of Three Types Of Dogs, American Pitbull Terrier, German Shepherd And Doberman
  6. Effect Of Cdp-choline To Reduce The Amount Of Necrosis Fibrouse Astrocyte In Cerebral Medula Of White Rats (rattus Novergicus) Exposed By Methylmercury
  7. Ethanol Extract Of Noni Fruit Activity (morindacitrifolia L.) Against Expressions Of Ifn- γ At Balb/c Mice Spleen Which Infected By Salmonella Typhimurium
  8. Study On Protein Expression Of Post-vaccination And Bird Flu H5n1 Virus Infection In Chickens
  9. Detection Diclazuril-resistant Eimeria Tenella At One Of Local Poultry In Kediri
  10. Combination Effect Of Echinacea Purpurea And Andrographis Paniculata As Hepatoprotector In White Rat Exposed By Heat Stress-
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