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Veterinaria Medika

ISSN 1979-1305

Vol. 3 / No. 3 / Published : 2010-11

TOC : 8, and page :191 - 196

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Original Article :

Effect of complex of insulin like growth factor-1 and insulin like growth factor binding protein-3 on the increase number of ovarian follicle in female mice (mus musculus)

Author :

  1. Gracia Angelina Hendarti*1
  1. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

This was a laboratory experimental study conducted by using isolates of IGF-1 and IGFBP-3 protein complexes from bovine follicular fluid. The purpose was to increase obtainable follicular count in female mice. This study used complete randomized design. Collected data were analyzed by using ANOVA (Analysis of Variance) and, if significant difference was found, 5% BNT test was carried out. Twenty eight female Balb strain mice were divided into four experimental group, each group consisted of 7 mice. This experimental was intended to find the effect of isolated IGF-1 and IGFBP-3 complex on the increase number of follicular on the ovary count in female mice. The results showed increasing follicular count in three treatments (P<0.05). The highest was found in third treatment (P3), in which the dose of isolated IGF-1 and IGFBP-3 complexes was 50 μg, with average follicular count of 23.14 ± 2.41. Conclusion can be drawn that administration of isolated IGF-1 and IGFBP-3 complexes can be used to increase follicular count in female mice.

Keyword :

Insulin Like Growth Factor-1 (IGF-I), Insulin like Growth Factor Binding Protein 3 (IGFBP-3), ., ., .,

References :

  1. Brzozowski, A.M., F. de Bree and G. Dodson, (1998). Structural Studies on Insulin–Like Growth Factor. . : Expression and Purification
  2. Anonimus., (2004). Overview. Insulin- Like Growth Factor (IGF). The IGFs, Their Receptors, and Their Binding Proteins. . : International Society for IGF Research
  3. Adashi E.Y., C.E. Resnick, A.J. Dercole, M.E. Svobode and J.J. van Wyk, (1985). Insulin-Like Growth Factor a Intraovarian Regulators of Granulosa Cell Growth and Function. . : Endocrine Reviews


Archive Article

Cover Media Content

Volume : 3 / No. : 3 / Pub. : 2010-11
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  2. Centrifugation of goat semen at freezing process with some concentrate of egg yolk diluent to the quality of sperm
  3. Influence of the avian influenza virus subtype h5n1 infection toward sperm motility and life in long tail monkey (macaca fascicularis)
  4. Vfa concentration and acetate, propionate, butyrate molar proporsions rumen of ongole grade cattle with ammoniation rice straw, soybean straw and rice straw
  5. The activity of achyranthes aspera linn alkaloid to cause aopoptotic and dna fragmentation on breast cancer
  6. The antimitogenic effect of alkaloid achyranthes aspera linn on apoptotic induction in cell infection by mycobacterium tuberculosis
  7. Stages of vaccination and the type of vaccine used to prevent infectious disease in chickens
  8. Effect of complex of insulin like growth factor-1 and insulin like growth factor binding protein-3 on the increase number of ovarian follicle in female mice (mus musculus)
  9. Spleen weight and white pulp diameter picture in broiler chickens exposed to cronic heat stress
  10. Identification of kit-ligand from in vitro maturation of bovine oocytes with electrophoresis method
  11. Cellulolityc bacteria for increasing quality of complete feed from waste product
  12. Identification of cyclin-dependent kinase (cdk1) that express on bovine cumulus oocyte complex after a model oocyte maturation experimence
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  16. Identification of the gene for staphylococcus aureus toxic shock syndrome toxin-1 (tsst-1) from bovine mastitis milk